Rechârge Biomedical Clinic

“Days of our years, in them are seventy years, and if, by reason of might, eighty years, Yet is their enlargement labour and vanity, For it hath been cut off hastily, and we fly away. -(Psalm 90:10)”

Septuagenarian blues

The survival curve above shows that a medical breakthrough might cure or mitigate one disease, but the curve hits a wall between 70-80 years. No matter what you do, stem cell aging catches up with you.

“If it’s not one thing, it’s another”

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We believe that the shortening of telomeres in stem cells causes many of the problems associated with advanced age.

So what is a septuagenarian to do?

Let’s review Homo sapiens’ progress thus far:

Homo Sapiens' lifespan

Curve A shows that a mere 50% of hunter-gatherer men made it to age 17…. (lions and tigers and beri-beri, oh my!)

Curve B shows that at turn of the 19th century, half those born in 1855 managed to celebrate their 45th birthday. Industrialization, sanitation, and social reform probably had a lot to do with that.

In 2009, despite modern medicine and the wealth of industrialized countries, Curve C is the best we can manage. As a species, we can split the atom, observe the birth of black holes, and compose Bach’s Mass in B Minor, but we’ve hit the limit of what good genes, clean living, and medical science can do.

The goal of telomerase activation with TA-65 is to move our survival curves to the right and create a new and improved Curve D.

Think of it like refurbishing a classic car with new parts. As long as you can stay on the high part of the curve, adding birthday candles beyond 70 won’t be “labour and vanity” because your quality of life will remain good and you will have plenty of friends still around to celebrate with you. As for being “cut off hastily” and “flying away,” Saint Peter will just need to reschedule.

Find out more about aging at www.RechargeBiomedical.com

Good health to all,
Dr. Park

I think I’m supposed to post this in order to join the “blogosphere.” Here goes nothing…

Technorati Profile

In the 1930′s, twenty years before Watson and Crick described the DNA’s double helix, Herman Muller was irradiating fruit flies at Woods Hole to produce mutants with deletions and inversions involving the ends of chromosomes. High energy rays produce DNA breaks, which is why UV exposure gives us skin cancer.

Of note, he never found mutants with deletions or inversions
involving the natural ends of the chromosomes and concluded that:

‘‘. . . the terminal gene must have a special function, that of sealing the end of the chromosome, so to speak, and that for some reason a chromosome cannot persist indefinitely without having its ends thus sealed.’’

Muller coined the term telomere for this terminal gene from the Greek, meaning simply ‘‘end part,’’ but the fact that this region of the chromosome deserved a specific name was a recognition that something unusual was going on there.”

(The above was excerpted from: The Plant Cell, Vol. 16, 794–803, April 2004,)

Muller used experiment and observation to correctly deduce the function of telomeres long before we even knew the structure of DNA.

All too often, truth often has to wait for consensus and dogma to catch up. In the case of telomerase activation science, let’s hope it doesn’t take the seventy years that it took for Herman Muller to be vindicated by Maria Blasco’s work.

Can you really afford NOT to take TA-65?

Great health to all,
Dr. Park

P.S. To see experimental proof of telomerase’s role in preventing chromosomal damage, go to http://www.rechargebiomedical.com/stemcells.html

I am posting an email from Aubrey deGrey’s Strategies for Engineered Senescence (SENS.) I attended the 2008 meeting at UCLA ( see http://www.sens.org/ADCI/ and it was simply amazing.

If you have a science background and can make it, you will not be disappointed!

In fact, that is where I learned that we are always making 10,000 new brain cells a day. Ask any physician and they will regurgitate the dogma that we don’t make new neurons. How wrong could we be for so wrong for so long? Find out what else you don’t know at www.rechargebiomedical.com/aging.html

My apologies if you receive this email more than once (or if you have already registered!). Please forward it to any colleagues who you feel may be interested.

I am writing to remind you that THIS COMING MONDAY, June 15th, is the deadline for discounted registration and abstract submission for the fourth Strategies for Engineered Negligible Senescence (SENS) conference, to be held at Queens’ College, Cambridge, England on September 3rd-7th 2009. After the deadline, both student and standard registration fees rise by £150.00. Also, after that date, we cannot guarantee that submitted abstracts will be considered for oral presentation or that they will be included in the conference abstract book.

All details of the conference, including forms for abstract submission and online registration, are at the conference website:

http://www.sens.org/sens4

The conference program features 45 confirmed speakers, all of them world leaders in their field. As with previous SENS conferences, the emphasis of this meeting is on “applied gerontology” – the design and implementation of biomedical interventions that may, jointly, constitute a comprehensive panel of rejuvenation therapies, sufficient to restore middle-aged or older laboratory animals (and, in due course, humans) to the physical and mental robustness of young adults. The list of sessions and confirmed speakers is as follows:

SENS Lecture:

• Moses Znaimer, media mogul and founder of the Canadian Association for Retired Persons
• Combating oxidation:
  Vladimir Skulachev, Holly Brown-Borg, James Joseph, Cathy Clarke
• Optmising metabolism against aging:
  Stephen Spindler, Stephen Vatner, Rafael de Cabo, David Melzer
• Adult regenerative capacity:
  Brandon Reines, Jonathan Tilly, Alexandra Stolzing
• Eliminating recalcitrant intracellular molecules:
  William Sly, Ana Maria Cuervo, John Schloendorn, Claude Wischik
• Rejuvenating extracellular material:
  Nik Nikitin, Mark Pepys, Sudhir Paul, Mark Noble, Roberta Cortivo, Kendall Houk
• Novel anti-cancer approaches:
  Paul Hallenbeck, Adela Ben-Yakar, Cassian Yee
• Telomeres and telomerase:
  Vera Gorbunova, Maria Blasco, David Keefe
• Rejuvenating the immune system:
  Janko Nikolich-Zugich, Anne de Groot, Omar Ali
• Delivering large structures in vivo:
  Pin Wang, Lusine Danielyan, Carlos Barbas
• ES-like cells and cell therapy:
  Justin Ichida, Ilham Abuljadayel, Thomas Zwaka, Daniel Kraft, John Sladek, Dan GazitM/
• Tissue engineering:
  Augustinus Bader, Gabor Forgacs, Sally Dickinson
• The longer term:
  Philip Moriarty, Tanya Jones, Leonid Gavrilov

In addition, there will be at least twenty short talks selected from submitted abstracts, as well as poster sessions each evening. Authors of short talks and posters will, like the invited speakers, be invited to submit a paper summarising their presentation for the proceedings volume, which will be published in the high-impact journal Rejuvenation Research early in 2010.

Please note that registration fees are fully inclusive of accommodation and all meals. Those not requiring accommodation, journalists wishing to obtain free press passes (not including accommodation), and those who are unable to register using a credit card are asked to contact me by email (aubrey@sens.org).

I hope to welcome you to Cambridge in September!

Cheers, Aubrey

Aubrey de Grey
Organiser, SENS4
Chief Science Officer, SENS Foundation
Editor-in-Chief, Rejuvenation Research

In case you missed it above, the biggest rockstar of all telomerase scientists, Maria Blasco, will be presenting. She is working closely with TA Sciences and Dr. Bill Andrews on an exciting new area of telomere biology that focuses on the effects of THE SHORTEST TELOMERES in the aging phenotype.

Good health to all,
Dr. Park

Thanks to Facebook and Noel Patton’s friend list,  I became friends with the world-famous Michael Fossel, founder of “Rejuvenation Research” (formerly The Journal of Anti-Aging Medicine.) He is author of two landmark books on anti-aging: In Vivo and Cells, Aging, and Human Disease.

Since I have been taking TA-65 for 20 months and since I believe the TRAP assays showing TA-65  lengthens telomeres, I was concerned about too much of a good thing.  You can find his reply at our forum:

http://www.rechargebiomedical.com/forum/viewforum.php?f=9&sid=8bafb8ffeb92d32807a97ce27df10147

Good health to everyone!

Dr. Park