Rechârge Biomedical Clinic

At the end of this post, you’ll hear from Don Biondich, who has ridden his ‘hog’ on six continents and was a certified pilot of nearly every kind of aircraft class… that is before his vision was ravaged by Macular Degeneration.

Don Biondich, one cool hombre

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Age-Related Macular Degeneration (AMD) is a loss of vision because of deterioration in the central portion of the RETINA (the inside surface of the eyeball upon which optical images are focused and then interpreted into sight by rods and cones connected to your brain.)

AMD can be accelerated by genetics and environment, but the root cause, in my opinion, is the same as other age-related diseases such as diabetes, high blood pressure, heart disease, COPD, and cancer….

In my opinion, these conditions are all caused by telomere erosion, as explained in my “Stem Cell Theory of Aging.”

———————->>  If you actually attempt to read my perspicacious yet bemusing blogs, you are probably very smart and should be asking: “Come on Dr. Park, you think everything is caused by telomere erosion!  What is your proof?

Well, in 1999, a very interesting study was performed testing the relationship between retinal cells’ telomere length, senescence and population doubling counts.  And, in just a moment, you should understand it as well as I do!

——————–First, let’s first review a few facts that my blog readers already know:

1. Cells start with telomeres that measure 10,000 base pairs long but only 4,000 remain in your old age
2. Cells populations can double only 60 times before replicative senescence (via the Hayflick Limit) dooms their lineage. The study calls the number of times the colony has divided its “Population Doubling Level”  (PDL)

———————- Next, some jargon that you will need to understand this study:

• Bromodeoxyuridine (BrdU) is a synthetic nucleoside that is an analogue of thymidine (the “T” in the A+T & C+G DNA base pairings.) Antibodies specific for BrdU can be used to detect cells that are still actively dividing (i.e. not yet burned out).

• β-galactosidase is highly expressed and in senescent cells.

———————- And finally, we can all understand the study!

Invest Ophthalmol Vis Sci. 1999 Jan;40(1):197-202.
Beta-galactosidase histochemistry and telomere loss in senescent retinal pigment epithelial cells.

Matsunaga H, Handa JT, Aotaki-Keen A, Sherwood SW, West MD, Hjelmeland LM.

Department of Ophthalmology, University of California Davis, USA.

Abstract

PURPOSE: To investigate the relation of senescence-related beta-galactosidase activity and telomere shortening to replicative senescence in cultured human retinal pigment epithelial (RPE) cells.

METHODS: A human RPE cell line was serially passaged until 80% of cells were nondividing in a 72-hour 5-bromo-2′-deoxyuridine (BrdU) labeling study. Early- and late-passage cells were double-stained for BrdU and senescence-related beta-galactosidase activity (pH 6). The average chromosomal telomere length at several population doublings was estimated by Southern blot analysis after double digestion of DNA with RsaI and HinfI and using a telomere-specific probe.

RESULTS: BrdU-beta-galactosidase double-staining revealed an inverse correlation between the number of BrdU-labeled nuclei and beta-galactosidase-labeled cells as a function of population doubling level (PDL).

In plain English, that means the more times the colony had divided (PDL), the fewer viable (BrdU+) and more burned-out (Beta galactosidase +) cells there were.

At PDL 58, only 20% of all cells labeled for BrdU, whereas 57% stained for beta-galactosidase. The mean terminal restriction fragment length (TRF) was reduced from 10 kb in early (PDL 12) cultures to 4 kb in late (PDL 57) cultures.

In plain English, that means that after dividing 58 of the theoretical 60 times of the Hayflick Limit, only 20% were still alive, and 57% were burned-out.  The telomere length in cells that had divided only 12 times was 10,000 base pairs.  The telomere length in cells that had divided 57 times was only 4,000 base pairs.

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Last week, the FDA approved an embryonic stem cell trial for treatment of Macular Degeneration, which is very promising since there is currently no adequate treatment for the condition which is known to affect 2% of those over 50, and 30% of people over 75.   And in my opinion, if people could live that long, it would probably affect 99% of people over 130.

Now, as promised, Don’s email from last week:

Dr. Park,

I would like to share with you my results using TA 65.

I am 76 years old and in great health for my age. I do have a problem with my eyesight. I have had dry macular degeneration in my right eye for years, however, my eyesight was still excellent. Within the last year and a half my eyesight started to diminish. It is not due to my macular degeneration but rather a loss of vision acuity. All of the ophthalmologists that I consulted said that although I will not go blind my eyesight is slowly going to get worse, so much so that in a couple years I will not be able to drive a car.

Then I saw your TV interview about TA-65 and other news releases on this product and was intrigued about the positive results with eye problems. I am taking four capsules every night and have been doing so for a little over a month. I have noticed that my overall health has improved to the point that I can now stand up from a sitting position without the aid of a product. Now this could be a placebo effect however, I have definite measured results that are very positive as far as my eyesight is concerned.

A grid like Don's describes

Because of my macular degeneration I have been using a grid chart for years to make sure that the dry degeneration does not turn wet which is serious. Since I have been using TA-65 the area of the grid chart that used to be distorted is now diminishing and I can see more of the chart that is not distorted.

The other positive results are that I can now use my computer with much more ease and less straining of my eyes. I like to play solitaire on my computer and the cards, of course, are much smaller than regular deck. Before the treatment I had some difficulty in distinguishing the number eight or nine card. I now can make this distinction and I think this is quite amazing and is a positive measured result.

Also, my vision for distance is improving. The reason I can judge this positively is that as I was experiencing the diminished sight I would practice looking at objects around me. Now these objects are getting clearer and brighter.

I will continue with the program and keep records of my improvements.

Thank you very much for your help and guidance,

Regards,

Don Biondich

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Disclaimer: The preceding testimony is presented as only one man’s experience.

TA-65 is not a cure nor a treatment for AMD.

Patients often wonder if after stopping TA-65, their cells will age even faster.  The answer is no; although unpleasant physical withdrawal symptoms are a common complaint after stopping anabolic hormones such as HGH (Human Growth Hormone) injections and sex hormones (testosterone and estrogens.)

Unlike hormones, Telomerase activation doesn’t supercharge gene expression,  it merely recharges the protective length of telomeres, like rechargeable batteries. That charge will then be shared with neighboring telomeres by rebalancing and prevent chromosomal damage that can lead to many, if not most, human diseases.

The musical, Bye, Bye Birdie asked: “What’s the matter with kids today?”

Well, if they inherited their parents’ telomere erosion, there would be a lot wrong with them! They’d be born older and with the DNA damage that mom and dad had acquired before reproducing.

But when a new life is created in a single cell fertilized egg, the telomere length is magically reset, like a pinball machine, to 15,000 base pairs, and the integrity of the DNA library inheritance is nearly error-free from highly error-protected egg and sperm cells.

A lot of cell division means a lot of telomere loss

In fact, because of the frenzied in utero growth and differentiation, you had already burned through 5,000 base pairs, so that on your birthday, only 10,000 remained.

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Since birth, you have lost and average of 1,000 base pairs per decade but lost them faster during stress, whether infectious, toxic, emotional, or from overuse. So, if you’re 60 years old, they could be as short as 4,000 base pairs in some types of stem cells.

Telomerase moves you back up the escalator

Think of your body’s stem cell telomere maintenance efforts like a an effort to walk or run back up a downward-traveling escalator.  Unlike run-of-the-mill cells, which die off from natural telomere shortening, stem cells use telomerase activation to print more and more telomere length.

Unhealthy living slows your upward movement, and may even make you descend faster towards the basement. In contrast, healthy living, via telomerase activation, allows you to run back up the escalator.  Since stopping TA-65 doesn’t speed up the escalator,  you will simply resume your descent from a higher level.

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Telomere erosion can be slowed or even reversed by telomerase activation, whether by exercise, good nutrition, psychosocial and emotional balance, or sleep.  Now, TA-65 is available to you as the world’s first safe and effective telomerase activator.  Think of it as an hour of cardiovascular exercise, four servings of fruits and vegetables, an hour of prayer or mediation, and eight hours of sleep, all in a tiny capsule!  Taking TA-65 is a way to reap the benefits of a healthy lifestyle for people who don’t have the time, inclination, or discipline to do so but do have the equivalent of a Grande Latte and muffin ($6.60) to spend on themselves daily.

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Postscript: For more inspiration from a real-life ‘windmill tilter,’ check out this story about an 80 year-old gentleman named Peter Hildreth who was banned from running up escalators.

People never change...only their stem cells do

We often think of our bodies as though they were machines.

But machines break down with usage, primarily due to friction.

In contradistinction, your body improves with overuse.  That is to say, more exercise makes your body stronger.  Do you know why?

Exercise activates telomerase

It is because exercise activates telomerase, just like taking TA-65!

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Elizabeth Blackburn, PhD- Nobel Prize winner 2009

Nobel Prize winner, Dr. Elizabeth Blackburn, studied men with prostate cancer and showed that their telomerase activity could be increased by just three months of these healthy behaviors:

1) a diet of low fat, whole foods such as fruits, vegetables, unrefined grains, and legumes, which was also low in refined carbohydrates

2) moderate aerobic exercise (walking 30 minutes/day, 6 days/week)

3) stress management (gentle yoga-based stretching, breathing, meditation, imagery, and progressive relaxation techniques 60 minutes/day, 6 days/week), and a 1-hour group support session, once per week

4) Taking supplements of soy, fish oil, vitamin E, selenium, and vitamin C

Dr. Blackburn’s research suggests that healthy lifestyle choices may be acting via one final common pathway: telomerase activation.  And now, there is a safe way to activate telomerase that over 1,000 people have taken since 2005.

——————— Nature’s experiments ——————–

Not convinced? Consider Nature’s experiment of people completely devoid of telomerase activation, a disease called Dyskeratosis Congenita. Those kids die by age 12 of age-related illnesses such as heart attacks and cancer (N.B. their cancers suggest that chromosomal damage from telomere instability causes cancer, not telomerase activation as the naysayers of TA-65 say, unencumbered by data or a sound theoretical basis.)

Dyskeratosis Congenita suggests that your life expectancy without any telomerase activation is a meager 12 years. The fact is, the more telomerase activity you can muster, the better.

Two other validations of improved longevity being associated with increased telomerase activity come from Ashkenazi Jews who lived to 100 and trees that lived to 5,000 years .

I believe that the other major theories of aging, such as intracellular junk and oxidative damage, are off the mark.  But you might cry foul and tell me:  “Dr. Park, ‘when all you have is a hammer, everything looks like a nail.’ Aging isn’t all attributable to the telomeres and the only reason you think so is because you’re selling TA-65.”

But I would reply that with 92 nails per cell (i.e. telomere caps) and the need to copy and protect them 4.8 trillion times a day, you had better have a lot of hammers at work. The experiments of a Nobel Prize winner AND Mother Nature, as well as the benefits that we, the TA-65 pioneers, have enjoyed, all suggest that telomerase activation is strongly associated with healthier lifestyles and healthier living.

When all you have is nails, you better have a lot of hammers

Taking TA-65 is a safe and natural way to increase your telomerase activity and we believe that is a good thing.   Call me if you would like to join our revolution against aging because “the proof of the pudding is in the eating” and the only way you’ll ever be truly convinced is to what I did: try it yourself.

“For death begins with life’s first breath…and life begins at touch of death.”
- John Oxenham

Your lung function, as measured by FEV1 (forced expiratory volume in 1 second), is highly correlated with of your age and your risk of dying. Mostly because of the inevitable aging of your lung’s stem cells, your measured FEV1 will decrease an average of 1% a year.

Lung capacity declines as you age

So starting from an optimal age of 25, a 65 year-old has lost about 40% of his lung volume and that loss will be ongoing and progressive.

Larry was a 65 year-old healthy man who underwent biometric testing before and after taking the supplement TA-65. He changed nothing else in his lifestyle and yet his lung functioning went from a very respectable 3.8 liters to 4.6 liters after only 15 months.

The skeptics among you will say this is just one case, a mere anecdote, and it could represent measuring error, placebo effect, or fraud.

I assure you that these changes are real, but even more compelling is the fact that they did not occur in isolation. In fact, all his objective measurements of aging improved.

His circulation improved dramatically because of softening of his arteries and his vision improved as well, owing to a softening of his lens.

I’ve personally been taking TA-65 for three years and I can tell you that the change is gradual, without any psychotropic or anabolic effects, which is why most people won’t perceive the ongoing improvements. That’s why as a patient of Recharge Biomedical Clinic, we will establish your objective organ reserves so that there can be no doubt about your cellular rejuvenation after taking TA-65.

Improved lung function creates better health and well-being and that is exactly what Mr. Simpson describes in this CBS news story. Take advantage of this safe and natural telomerase-activating technology to RECHARGE your vitality as well.

Please call or email us with your questions today because we look forward to helping you start your journey back to a more youthful and hopeful you.

“Most persons have died before they expired – died to all earthly longings, so that the last breath is only, as it were, the locking of the door of the already deserted mansion.”
-Oliver Wendell Holmes