Rechârge Biomedical Clinic

Recharge Biomedical “PODCAST 012: Exercise”

Dr. Ed Park of Recharge Biomedical explains the simple cause for most cancers and how Telomerase Activation prevents them, not causes them.

Podcast 4 – Lung Cancer with Jacky Rose, RN
Dr. Park explains lung cancer and interviews a patient battling its most aggressive form. While taking TA-65 she cleared tumor that had spread all the way to her brain and he maintains a high quality of life well past the time that 99% of most patients would have died.

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Dr. Miki Shima and two of his many cancer patients discuss their positive experiences with TA-65 while battling cancer. Dr. Shima is an author and world-famous expert in Oriental Medicine.

Now, you can be sure to never miss a webinar by subscribing to our Podcasts. Click the iTunes Logo for more info.  By subscribing, future webinars will be automatically downloaded into your iTunes and then can be loaded onto your computer, phone, or device.

Yesterday, on December 9th, the Surgeon General released a 704 page report explaining that smoking is bad for you. The headlines were “A single cigarette can kill you” and  “85% of all lung cancer is caused by smoking.”

Regarding cancer, I definitely agree with these two statements in the executive summary:

“6. Exposure to cigarette smoke carcinogens leads to DNA damage and subsequent mutations in TP53 and KRAS in lung cancer.

7. There is consistent evidence that smoking leads to the presence of promoter methylation of key tumor suppressor genes such as P16 in lung cancer and other smoking-caused cancers.”

Failed DNA repair – the common theme for Cancer and Aging

Have you noticed that when someone gets lung cancer, the question that always follows is “was he/she a smoker?”  No one asks if the person lived near radon or had unhealthy lifestyles (poor nutrition, stress, lack of exercise) that shorten telomeres.  Have you ever heard of a partner getting cancer a year after their spouse died of cancer?  We know that Cancer isn’t contagious, so how is that possible?  I believe the stress they went through must have inhibited their telomerase activity, allowing their telomeres to erode more rapidly.

Yesterday’s report states that 85% of lung cancer is caused by smoking.  But this conflicts with most previous studies showing that the majority of deaths from lung cancer are NOT statistically attributable to smoking?  It could also be that 85% of all people have tried a cigarette and that is why 85% of all lung cancer patients have a smoking history. But is that causation?

Perhaps for our own good, the report declares that a single cigarette can kill you.  But note that the same statistical, but not necessarily causal, association would exist between the percent of American’s who have kicked a soccer ball and any other disease group you wish to study.  For example 85% of people who are struck by lightening have kicked a soccer ball.   85% of people who lose a limb in industrial machinery accidents have kicked a soccer ball…etc.

The following paragraph more closely resembles the traditional epidemiological dogma with regard to smoking and lung cancer:

“52.2% and 14.8% of lung cancer deaths were attributable to current and former cigarette smoking, respectively. In females, the corresponding figures were 11.8% and 2.8%. Among current male smokers, the relative risk was strongly correlated with the intensity and duration of cigarette smoking. “

Ando et al, International Journal of Cancer, Volume 105, Issue 2, pages 249–254, 10 June 2003

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"There are three kinds of lies: lies, damned lies, and statistics."

I am not trying to say smoking is not bad for you.  It most certainly is.  But it is also important that epidemiology not be distorted to further an anti-smoking agenda.

People often conceptualize cancer as a genetic lottery or moral retribution.  But as I explain in this video, I believe that Cancer’s are largely made possible by telomere erosion and failed immune surveillance.  Here are some other facts that may surprise you:

• Did you realize that 2/3 of people with any cancer don ‘t have a prior family history for that particular cancer?

• Did you realize that if you live long enough, you will get cancer of every organ?  It’s just like if you drive your car for 1,000,000 miles, all the car parts will fail.  When you change the transmission at 400,000 miles, you don’t blame abuse of the car or remember that your sister’s transmission failed as well.

To reiterate, smoking does cause lung cancer and many other illnesses and is a bad thing to do.   But as this JAMA article suggests, the telomere erosion occurring in all stem cells is probably the major mechanism for cancer formation in all your organs and is reversible by telomerase activation, whether by TA-65 or other healthy lifestyle choices.

Old paradigms must make way for newer ones.  There are currently 3,924 articles that come up when you type “telomere and cancer” into PubMed.  Academics advance science incrementally. “Publish or perish.”   But you can take advantage of a safe and natural quantum leap in DNA repair.   “Refurbish or perish” should be your motto and that’s not just spin doctoring.

(note: there is an essential video that accompanies this post at the bottom of the page.)

Cancer is hard to define. Would-be cancer cells are routinely destroyed by your immune system prior to becoming clinically apparent.  That may have happened billions of times already but “if a tree falls in the woods, and no one hears it…”

Cancers can also fail to travel or invade very well, leading to cancers of “low malignant potential” that you can live with indefinitely, like Steve Jobs’ Neuroendocrine pancreatic cancer.

And if cancer-like behavior, such as loss of contact inhibition or uncontrolled replication, occurs in a telomerase-inactive cell, then its lineage is dead within 50 divisions due to the Hayflick limit, so who cares?

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What we can say without hesitation about both Cancer (and Aging) is that they may not be diseases like Scurvy (Vitamin C deficiency) or a Heart Attack (coronary artery blockage) but they are both the result of DNA damage which can be caused by radiation, oxidation, but most of all, telomere shortening and dysfunction.

Since it is Breast Cancer Awareness month, let’s look at the infamous “breast cancer gene,” or BRCA1.   A BRCA1 mutation is associated with a 60% chance of breast and ovarian cancer by age 90.  But did you know that “BRCA,” although it sounds like “breast cancer,” is really named after Berkeley, California?

Even more surprising, BRCA1 is no more a “cancer gene”  than policemen are crime-inducers. They don’t cause cancer but if they aren’t policing the DNA, cancers will develop.

This policeman’s role of BRCA1 is to keep the telomeres healthy and repair DNA breaks. That is what they do 99.99% of the time. When a breast ‘stem cell,’ which is already immortal by virtue of telomerase activation, loses its heterozygosity (LOH), it loses its only good copy of the BRCA1 gene and then the “bad” copy (or no copy) is all that is left.  As a result, the cell can no longer protect the telomeres and bad things happen.

LOH occurs with high frequency in BRCA1 patients who get cancer because chromosomes are not evenly segregated between a cells two daughters, a process described in the video about chromosome damage at the end of this posting.

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In your car, friction causes your pistons to wear out, the brakes to fail, and the tires to go bald.

Just as motion creates friction in your car, so replicative senescence grinds down the cells in your body.  Cells are constantly “in motion” because they must copy their 46 chromosomes 50 billion times a day. With each division, telomeres shorten and that’s why cells age.

Analogies are not even needed when it comes to radiation and oxidative stress. Radiation can cause DNA breaks just as radiation causes paint to crack and upholstery to fade. And oxidation causes DNA damage in cells just as it causes rust to your undercarriage.

————Other cancer syndromes

In addition to BRCA, there are other gene defects which can cause cancer syndromes and they often relate to DNA repair, such as the Retinoblastoma protein and P53 (Li-Fraumeni Syndrome).

When I say there is only one cause of breast cancer, I mean that DNA damage is the sina qua non of all cancers. And when I say there are many cures, just look at this chart because all of these pathways are constantly at work to repair DNA or cause cell apoptosis (forced death) in order to prevent cancer. When any of them are disabled, as in the case of BRCA1 gene mutation, your DNA surveillance is compromised and like a city without cops, crime ensues.

Interestingly, 10 of 11 premature aging syndromes (aka Progerias) are related to DNA repair problems as I describe in this video, so the premature aging and the premature cancer syndromes are cut from the same cloth: failure of DNA repair and/or cell apoptosis.

Now that we have a telomerase activator in TA-65, we can assist DNA repair by preventing the telomere decay that causes breaks and incorrect chromosome separation at cell division.  Don’t let another day pass without naturally recharging your stem cells by safely activating your telomerase.

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To really increase your breast cancer awareness, you must watch this video which explains how DNA damage occurs and explains why cancer-prevention genes like BRCA1 are so essential.

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