Most people, physicians included, believe that high blood pressure is a disease but I am not alone in believing that it is really just an inevitable consequence of aging.

If you only remember one thing from this posting, understand that high blood pressure occurs because, like our aging skin, the arteries become less supple as we age.

The arteries are like garden hoses that can also pump.  That’s why you can feel your pulse in your wrist and neck.  Interestingly, healthy young arteries can pump harder as they get farther away from the heart, thereby helping out with some of the forward pumping workload of the heart. That is depicted on the left by the ‘fanning out’ of the pressure measurements from “Aorta” to “Large Artery” in this purple diagram. By the time you reach the capillaries, flow is pretty constant.

But with aging,  gunk accumulates as atherosclerosis, arterial walls thicken, and the contractions of your tired arteries weaken, so the body has to somehow compensate for a LOW blood pressure being delivered to vital organs by both increasing the output of the heart (like opening the faucet) and narrowing the flow (like kinking the hose or restricting flow with your thumb).

The medicines we successfully employ to control blood pressure most often dampen the body’s narrowing mechanisms such as the adrenaline system, the salt excretion system, and the active control of the arterial diameters (the renin-angiotensin system), mechanisms which are all commonly misconstrued to be causes of hypertension, rather than its mediators.

The new paradigm considers hypertension to be body’s cure for a critical but faltering task:

the need to deliver blood away from the heart

Same arm BP's, different central work needed

This diagram shows three men of different ages who have normal blood pressure measured by blood pressure cuffs found in your doctor’s office (that were incidentally invented over 115 years ago.)

So their circulatory systems are all the same, right?    No.  Dead wrong!   Because “110/80″ in the arm, whilst resting and seated, doesn’t tell us much about the accumulated aging of the arteries that the heart and central arterial system must contend with.

In order to maintain similar blood flow delivery depicted on the bottom chart, notice that the 28, 52, and 68 year-old heart/arteries produce very different Pulse Waves more centrally, as depicted on the top chart.  The remainder of this post explores modern Pulse Wave Analysis (PWA) that is not, but probably should be, used in your doctor’s office to understand your actual circulatory function.

——————– 21st century technology:  The Pulse Wave Analysis (PWA)

Even if you’re not a fluid engineer for NASA, you can intuitively grasp PWA by imagining you have a turkey baster that is tightly connected to a water balloon. If the water balloon is long and soft like the ones they make balloon animals with, you don’t get much bounce back on the bulb when you squeeze.

But imagine you have it connected to one of those little round ones that you can hurl at your friends; you would feel a regurgitation into your turkey baster bulb after squeezing, right?

The first, green wave of the PWA corresponds to the heart’s pumping outward (the baster’s bulb), and the second, red wave is the backwards pressure wave reflected back from arterial resistance (the water balloon’s reaction to your squeezing). The blue, third wave the sum of the first two and represents the all-important, central measurement that was shown in the three men above.

If the circulation is soft and the arteries are helping to pumping blood away, there is not a lot of reflection.

But when the arteries are hard and no longer help pump the blood away from the heart, this reflection, which was once hidden in the turkey baster wave, shows up as a distinctly separate bump now. That is called the Augmentation Pressure and is bad because it is reflective of, literally and figuratively, the hardening of the arteries and the increased blood pressure.  Higher pressure creates more turbulent flow and vessel damage, and causes the viscious cycle of atherosclerosis and the other so-called ’causes’ of hypertension (adrenaline, salt, and the renin-angiotensin system) which I am trying to convince you are just the maladaptive, but required, adjustments needed to keep adequate blood flow in an aging circulatory system.

—————–  Is this still a 65 year old man?   Not so much…

A previous post documented our real-life Benjamin Button’s improvement in his reading glasses and far vision, which we speculated was caused by softening of his lens.  Well, his arteries also softened because his Augmentation Pressure dropped from 21 mmHg to 11 mmHg and his Augmentation Index dropped from 21% to 8% after a year of the Patton Protocol!!

His softer and better-pumping arteries were confirmed by a drop in his blood pressure from 140/90 to 110/60.   And no, our client was never on, nor did he start, any medications during this year and his weight and exercise regiment reamined exactly the same.   But he was taking TA-65 for that entire year.

If some of you still need more convincing, we’ve saved the best for last with for our next ‘Benjamin Button-esque’  update about his skin and lungs.

But if you are now curious about your own circulatory age, even on current medications, please call and schedule a free consultation.  Those who manage to schedule an appointment during September will receive their choice of either:

• complimentary Pulse Wave Analysis described here   or
• 50% off of the complete suite of Aging Biomarkers (vision, cognition, skin, pulse wave, and lungs. Special sales price is $250 but is Regularly $500.  Blood tests and TA-65 supplements are not included but there are no obligations and the consultation is free.)

Appointments are limited so call now and take advantage of our revolutionary technology, based on Nobel Prize-winning science, to reactivate your body’s own natural rejuvenation.  What have you got to lose?  Other than a few decades worth of aging, that is…

Between the age of 40 and 50, a universal sign of aging, farsightedness, begins. Also known as Presbyopia, the medical term comes from the Greek word for ‘old man’, presbys, and opia-sight.

The lens can be thought of as having a “Gummy Bear” viscosity, allowing it to flatten when fibers holding it from around its circumference, like the springs around a trampoline, are pulled open . The trampoline springs are themselves connected to and controlled by a relaxed circular muscle sphincter. This focusing mechanism allows you to see objects from distances of 1.5 inches up to infinity.

This oddly-conceived coffee table provides a good model if you see the table top as the iris which controls the amount of light that enters the pupil (open in dark, pinpoint in the bright sun).

At rest, the muscle that controls the trampoline (aka Gummy bear lens) is a big circle so that the lens is maximally flat and permits viewing of objects that are far away.

——————————————-NEARSIGHTEDNESS—————————-

With Myopia (aka nearsightedness), you need glasses to see objects that are far away because the lens focuses the image before the back wall of an egg-shaped, myopic eye:

But keep in mind, the problem with nearsightedness is not the lens. It is as though you had moved a slide projection screen farther away after the focus had been established.

————————————FARSIGHTEDNESS—————————————

To focus on objects that are progressively nearer, like newspapers and prescriptions bottles, the circular muscle will constrict, thereby letting the ‘trampoline springs’ slacken, which in turn, permits the central Gummy Bear/lens to become rounder.

So you need reading glasses as you age because even with the circular ‘lens sphincter’ becoming its smallest circumference, the Gummy Bear has become too hard to take on its rounder, more light-refractive state.

And if you have an egg-shaped eye AND your lens has become a harder Gummy bear, you’ll have myopia and presbyopia and you’ll be needing need bifocals or two sets of glasses.

————–
Reading glass strength is measured in diopters. Click here for a site to test your own eyes.

Although just anecdotal, one of our recent 1 year follow up patients, a gentleman 65 years of age, actually had his reading glass prescription weaken from 2.5 to 2.0 diopters. While taking TA-65, his lens must have become softer.

Even more surprising were the radical improvements in his myopia reflected in his farsighted vision. This might also be attributed to the softening of the lens, thereby allowing the maximally relaxed sphincter and its trampoline springs to pull the lens flatter.

———————
In isolation, there may be a simple explanation. But over the next two posts, we’ll share his improvements in lung capacity and arterial stiffness, which are also universally-deteriorating signs of aging. Together, these improved biomarkers paint an picture of a man growing younger!

The news yesterday was of a new class of drug to fight melanoma using a new mechanism: it boosts your immune system instead of destroying it.

I created this diagram to illustrate the treatment of cancer as of 2010:

But as with many things, best treatment for cancer is prevention. If you protect the tips of the chromosomes (the TELOMERES), you don’t get the recombination and breaks that cause cancer.

The second best the p53 enzyme, the “watchman of the genome”, which repairs DNA, causes damaged cells to stop dividing, or destroys them outright.

The third line is the adaptive immune system of the T Cells, especially the Natural Killer cells. Check out this link to see how your body has possibly cured you of cancer millions of times already.

Once cancer becomes clinically-evident (like the weeds above ground in this diagram,) treatment becomes increasingly destructive from precision surgery, to local radiation, to systemic chemotherapy.

The efficacy of radiation and chemotherapy comes from targeting rapidly-producing cells.  Unfortunately, your own body’s stem cells are also rapidly-producing. So the cure is often worse than the disease and at the very least, it makes it harder to fight the disease

Would you put down a student protest....

.... by dropping napalm on campus?

Returning to our pyramid diagram, an ounce of prevention is better than a pound of weed-killer, or scorched earth.

Telomerase activation occurs with rest, exercise, good diet, and taking TA-65.

To learn more about the link between cancer and telomeres check out this link.

Today is Memorial Day here in the United States, a day when we honor those who died during war.  For some historical perspective, here is a list of the seven most lethal wars that mankind has faced.

The Seven Deadliest Wars:

#7 Vietnam War (1968-75) - 2.5M killed

#6 Korean War (1950-52) - 2.5M killed

#5 Second Congo War (1998-2003) - 3.8M killed

#4 Russian Civil War (1917-1921) - 5M killed

#3 World War One (1914-1918) - 10M killed

#2 World War Two (1939-1945) - 40M killed

#1 War Against Aging (50,000 B.C. - present) 100 Billion killed

In this  “War Against Aging”, an individual’s weapons were limited to rest, exercise, nutrition, and herbs.

Cultures waged their battles against oblivion using prayers and sacrifices, having descendants, fighting wars, or creating art and ideas of lasting value.

But the winds of war are shifting against our ancient enemy of aging, which has slain 94% of its combatants (100B of the 106B Homo sapiens that have lived.)

Because just as we harnessed the power of the atomic nucleus to deter war, science has harnessed the power of the cellular nucleus to deter aging.

TA-65 is simply a scientifically-proven, MAGIC BULLET to defeat the Grim Reaper by refurbishing and recharging your DNA protection at the genetic level.

To enlist in our “War to End All Ends,”  visit:

http://www.rechargebiomedical.com/aging.html

With the current furor over Tiger Woods and ARod’s doctor
being busted for treating high profile athletes from MLB and the NFL, we should revisit the facts about ANABOLIC substances that cause increased muscle mass through altered gene expression.

All the world loves a winner and the undeniable truth is that ANABOLIC substances such as testosterone and HGH, do make professional athletes run faster and hit balls harder. And doing those things sells TV ads and fills stadium seats.

But even for the weekend warriors, it has been common for men concerned about aging to take Human Growth Hormone (HGH) and other male hormones, which include tetrahydrogestrinone (THG), androstenedione, and testosterone.

If you think of your body like a car, then anabolic substances cause a supercharging and that burns through your stem cells and may ironically cause premature aging!

In contrast, telomerase activation is regenerative, leading to improved function by naturally rescuing senescent or dormant cells. Your metabolism increases only as a result of firing on “all cylinders”, not because of adding supercharged intake and exhaust and ‘red-lining’ at 9000 RPM’s

When people ask whether taking TA-65 is safe, I say yes because we know the three dozen or so genes that it modulates thanks to these amazing “gene chips” that measure the 25,000 known human genes on a device about the size of a postage stamp.

Interestingly, most of the genes activated by TA-65 are involved in DNA repair and rejuvenation, which are undeniably GOOD things.

In contrast, anabolic steroids like testosterone alter genes expression in almost a thousand genes!

To learn why non-anabolic telomerase activation is safer than the current “anti-aging” fads of HGH and male hormones, go to http://www.rechargebiomedical.com/taisnotanabolic.html

On March 30th, some Über-geeks fired up their Large Hadron Collider in Switzerland in an effort to move one huge step closer to Einstein’s elusive lifelong dream of a G.U.T. or Grand Unified Theory.  That ‘theory of everything’ is a somewhat verifiable way to explain how the particles of the Standard Model of particle physics fit with our understanding of Electromagnetism, Strong and Weak nuclear forces, and Gravity.

I know what you’re thinking:

“Zzzzzzzz…BOh–ring”

But WAKE UP! To paraphrase the Baby-Boomers’-Bard, “The future now, will later be past.”

The story of how firing up the big blaster didn’t end the universe was eclipsed in the headlines because 1) it didn’t affect the survivors of Oceanic 815 and 2) it’s not as riveting as Kate Gosselin’s fate on Dancing with the Stars. I get that. But explaining the whole universe is pretty good for a species of “Monkey-boy” hominids that have only been in existence for a mere 200k of the universe’s 13.7 billion years, or 0.000014 of its creator’s existence. This would be probably as likely one of your dust mites writing your entire life story into a Tony-award winning musical during a commercial break of Dancing with the Stars.

So if these acne-stricken, Toblerone-scarfing smarties find their Higgs Boson particle (or Dan Brown’s ‘God Particle’ from Angels and Demons) they’ll be closer to unifying their models and better still, their mom’s get to tell their ‘Frenemies’ how their kid turned out to be smarter than Einstein.

I know what you’re thinking:

“Where the $*@! is he going with this?”

In 1986, Sean Connery played a 14th century theologian/gumshoe named William of Ockham in a pretty cool whodunit movie called The Name of the Rose.

He (Sir William of Ockham, not the greatest James Bond of all time) is best known for his principle of “Ockham’s Razor,”  which has been a close companion of scientists and detectives from Carolus Linnaeus to Lieutenant Columbo:

pluralitas non est ponenda sine necessitate

“plurality should not be posited without necessity”

In other words, don’t evoke a whole bunch of reasons when only one will do just fine.

So that’s really the point of this posting.   To explain aging, theorists often focus on the results of human aging, not its root cause, which is likely to be telomere erosion.

Since telomere erosion allows the ends of all DNA to be exposed and injured, it is sufficient to explain and encompass all the other theories such as:

• Error Accumulation
• Somatic mutation
• Accumulative-Waste
• Free Radical theory
• Mitohormesis
…etc.

To paraphrase another pretty cool movie “One theory to rule them all, one theory to bind them…”

It seems logical that if every living creature with non-circular DNA uses telomerase to protect their DNA libraries, despite having evolved a variety of different repeating sequences, then the evolutionary conservation of telomerase must be a necessary condition for the survival of any species that carries the entire library in every cell nucleus.

Since the “Grand Inquisitors” these days are physicists and not sadistic zealots, anyone can come up with a theory. Even I did. If you want to check out my theory of aging, go to: http://www.rechargebiomedical.com/aging.html

And if you want to do something logical and positive towards living healthier and longer, you should do what hundreds of MD’s, PhD’s, and CEO’s have already done: take TA-65 to activate your telomerase and repair your critically short telomeres. You have our MONEY-BACK GUARANTEE!

Although I’ve been taking TA-65 for two years, this pdf ( 6mos_telomeres ) that is attached shows the 6 month results from my first three Patton Protocol clients. Everyone feels great and the gains are nothing short of a home run.

If you can, please join us for tomorrow’s TA-65 webinar at 4pm PST (7pm EST):

“FROM TA Sciences- For IMMEDIATE RELEASE:

We’ll have Bill Andrews, PhD, co-discoverer of the hTERT telomerase gene, delivering a powerful presentation on Telomere Biology as it applies to your patients through the use of TA-65. We’ll also have an important discussion about “Resveratrol versus TA-65.”

There will also be docs on board for this webinar who are taking TA-65 themselves as well as using it in their practice. There will be ample opportunity for Q&A.

Plan to listen and/or participate in the webinar Thursday the 24th, from 7-9 PM (4PM PST)  by going to http://tasciences.com/live”