How telomere erosion leads to chromosomal mutation, which causes dysfunction and cell death (we hope)
Just a link for those of you who may not know what telomerase is, what it does, and why it is crucial to slow aging.
Failure to faithfully replicate and preserve stem cell DNA appears to be the final common pathway to premature aging
I was at an ideas festival filled with some bright and accomplished people and I found myself rebuked by what I would consider true ignorance at least three times.
In my search for wisdom about aging, I maintain that the primary cause is telomere shortening. This does not mean that methylation, signaling with stem cell produced vesicles (like packages with a purpose) don’t play a secondary role.