Podcast 33: “TA-65 : The FAQ Show.”
TA-65 stands for “Telomerase Activator-65”
In 2001, a world-class biotech company named Geron made a landmark discovery. The scientists at Geron Corporation discovered TA-65®, a proprietary, single molecule purified from Astragalus Botanical Roots that causes Telomerase Activation (TA).
Astragalus has been used for centuries as a Traditional Chinese Medicine (TCM). Its usage dates back to the late Han Dynasty (206 BC) when it was considered a “heaven class” herb due to its anti-aging properties associated with an extended life span.
Like Ascorbic Acid (aka Vitamin C,) which occurs in many edible plants, TA-65 is considered a Nutraceutical.
TA-65® is NOT the same Astragalus extract products commonly found in herbal and vitamin shops. There is no ongoing monitoring of people taking them so we don’t know what the results may be.
Proprietary Process for Extracting Purified TA-65
T.A. Sciences is committed to ensuring the highest quality from end-to-end of the supply chain. After more than three years of research and development, T.A. Sciences in conjunction with experts in Canada, Hong Kong, and the U.S. has perfected a proprietary method for extracting the naturally-occurring TA-65 molecule from the Astragalus root. It cannot be synthesized and has to be extracted.
First, T.A. Sciences harvests plant material from specifically selected farms in one small region in China. After initial extraction, the base ingredient is further purified and then sent to an outside government testing facility where it is tested for purity, heavy metals, and pesticides.
Next, this base material is sent to T.A. Sciences’ contracted laboratories in Canada. Each shipment is accompanied by a verified Certificate of Analysis, ensuring the identity and purity of this material. The Canadian laboratory is a modern state-of-the-art facility certified to produce drugs to FDA standards. There, the base material is further processed to yield the single TA-65 molecule. After being refined to over 90% purity, each batch goes through a final inspection, using a proprietary, patent-protected assay exclusive to T.A. Sciences.
From T.A. Sciences’ labs in Canada, the single molecule TA-65 is sent, again with an authenticated Certificate of Analysis to ensure purity, potency, and quality– to be formulated and produced into capsules by Garden State Nutritionals in the United States. T.A. Sciences can assure its clients of the highest level of quality, potency, and purity of TA-65 in each and every capsule. What we say on our label is 100% accurate.
TA Sciences has licensed TA-65 from the Geron Corporation. The telomerase-activating potency of TA65 has been independently proven in rigorous tests by Geron. Sierra Sciences, a biotech company specializing in telomere biology, has independently tested and found that TA-65 activates telomerase.
Proof of Telomerase Activation
Stem cell Telomerase Activation
Geron/TA Sciences verified the ability of TA-65 to induce the telomere lengthening in MRC-5 fibroblasts (skin stem cells.) The Telomeric Repeat Amplification Protocol (TRAP) assay confirmed telomere lengthening at TA65 concentrations ranging from 0.01 µM to 100µM (0.01,0.1, 1, 10, and 100 µM), with a subtle increase depending upon the dose.
Telomerase Activation in HeLA (immortal cervical cancer cells)
TRAP involves measuring the active lengthening of telomeres in response to some test condition, in this case, TA-65 exposure. it is interesting to note the a “ladder” is created because the telomeres are always formed in multiples of 6 base pairs, stamped out by telomerase from the active site, courtesy of activated telomeric RNA.
So you should be thinking, “if TA-65 induces Telomerase Activation in cancer cells, won’t it cause cancer?” There good reasons to expect it shouldn’t:
- It has been thoroughly tested in the Ames Assay and Xenografted nude mice. There wasn’t any evidence of carcinogenesis in the former nor clinical tumor enhancement in the latter.
- TA is already active in these cancer cells, so the necessary but insufficient condition has already been met. The Cancer Stem Cells theory proposes that stem cells are the cause of all clinically relevant cancers because they are self-immortalizing. So turning on telomerase is like throwing matches on a campfire.
- Telomerase Activation might kill stem cells which have already mutated into dangerous combinations, like the Philadelphia Chromosome.
- Immune Health improvements fight cancer by T-cells and Natural Killer function.
- It has been ingested since 2005 by over 100,000 people and there has been no discernable increase in cancer or pattern of side effects
FULL DOSE Option (1000 units) – Recommended
TA-65 / 1000 units (4 capsules daily) – this is considered the FULL DOSE and is recommended for clients who are of:
ANY AGE and have reason to believe that strengthening their immune system would have particular benefits.
ANY AGE and have measured their telomeres and found them to be short.
It is expected that this dose will give an increased benefit over the lower doses (although not a proportional benefit). Study subjects experienced lengthened telomeres, restoration of weak immune systems, bone density improvements and other important bio marker improvements which usually decline with age. Anecdotal reports include energy increase, endurance, cognitive improvements, improved vision, sexual enhancement, and an overall feeling of well being. You will receive 8 bottles, each containing 90 capsules.
Price: 8 bottles for each six month segment = US $4,000 (savings $800)
Orders of 8 bottles or more receive a discount of $100 per bottle. You may stock up on the bottles regardless of your dosing plan to receive the discount.
Medium Dose Option (500 units)
TA-65 / 500 units (2 capsules daily) – this medium strength dose is recommended for people who are generally in good health and want to be proactive in longevity and healthy aging. You will receive 4 bottles, each containing 90 capsules.
Price: 4 bottles for each six month segment = US $2,200 (savings $200)
Low Dose Option (250 units)
TA-65 / 250 units (1 capsule daily) is efficacious for healthy adults. Also 250 units can serve as a maintenance dose for people who have been taking higher doses of TA-65 for several years and want to continue on a reduced cost program. You will receive 2 bottles, each containing 90 capsules.
Price: 2 bottles for each six month segment = US $1,200
Single Bottle (250 units)
TA-65 / 250 units (1 capsule daily) is efficacious for healthy adults. Also 250 units can serve as a maintenance dose for people who have been taking higher doses of TA-65 for several years and want to continue on a reduced cost program. You will receive 1 bottle, containing 90 capsules.
Price: US $600
TA-65MD® 30 Caps (100 units)
TA-65MD® is formulated through a proprietary process to increase the absorption (bioavailability) of the TA-65MD® compound in the body. No other products utilize this proprietary technology.
TA-65MD® 100 unit 30 capsules are an ideal starter kit introduction to TA-65MD® at a lower dose. Most users will feel a benefit immediately even from this lower dose.
You will receive 1 bottle, containing 30 capsules.
Price: US $100