How telomere erosion leads to chromosomal mutation, which causes dysfunction and cell death (we hope)
Thankfully, telomere shortening causes them to mutate and mutation triggers self-destruction. What we want is to preserve the critical stem cells.
Titia de Lange, Ph.D., Leon Hess Professor; American Cancer Society Professor; Head, Laboratory of Cell Biology and Genetics; Director, Anderson Center for Cancer Research; Rockefeller University, New York.
Awarded the Gairdner Award for her discovery of the mechanisms by which mammalian telomeres are protected from deleterious DNA repair and damage responses.
Yesterday’s report states that 85% of lung cancer is caused by smoking. But this conflicts with most previous studies.