Telomere crisis results when the protective caps at the end of chromosomes, known as telomeres, become shortened as a result of cell divisions. With less DNA present in telomeres, it becomes harder to prevent separate chromosomes from attaching to each other. If those abnormal cells survive and continue to divide, they can give rise to cancer.
For today’s #WebinarWednesday, we return to the penultimate iHealthTube video interview. I explain why we are like cars and that with time, if we survive all our cancers, we would eventually accumulate them all. Just like if you drive a car for millions of miles, you will replace all parts.
Janet Rowley, MD, was known for proposing that cancers are caused by a genetic malfunction, more specifically by translocation of DNA from the ends of one chromosome to another. What is the process that allows this to occur? It is telomere erosion. This is the basis of my unified theory of aging and disease illustrated by this diagram from my book, “Telomere Timebombs: Defusing the Terror of Aging”