Janet Rowley, MD, was known for proposing that cancers are caused by a genetic malfunction, more specifically by translocation of DNA from the ends of one chromosome to another. What is the process that allows this to occur? It is telomere erosion. This is the basis of my unified theory of aging and disease illustrated by this diagram from my book, “Telomere Timebombs: Defusing the Terror of Aging”
The new paradigm is that cancers, like the cells in your healthy organs, are maintained by very rare Cancer Stem Cells (CSC’s).