My stem cell/telomere theory of aging and disease is a necessary and sufficient explanation for nearly every disease you can imagine
When I’m asked about experts’ opinions, I think of a Bob Dylan lyric: “Don’t follow leaders; watch the parkin’ meters.”
We have a long way to go before we can do more than identify and trust in the black box of stem cells
The fact that progeria-affected kids have undeniable biological aging despite young epigenetic and chronological ages implies that telomerpathies that drive them are still the most robust explanation for aging globally
Over time, the dutiful and dysfunctional stem cells die off but others, like the Mafia capos or career politicians, become unable to kill themselves so they persist and cause problems while still lengthening their telomres.