The reason telomerase increases the aging clock is because the lineage of incidental methylation increases. The longer a stem cell (and its incidental methylation) have existed- the dustier the top of the fridge.
In my search for wisdom about aging, I maintain that the primary cause is telomere shortening. This does not mean that methylation, signaling with stem cell produced vesicles (like packages with a purpose) don’t play a secondary role.
There was an article that hit the newswires suggesting that alcoholism is associated with shorter telomeres.
By using the Nine Bradford-Hill criteria, we can assess causation for just about anything
In this 2008 study of twins, British researchers looked at 52 pairs of identical and 15 pairs of fraternal twins and concluded that exercise, even after controlling for confounding variables of age, BMI, smoking, year of sampling, and socioeconomic status, was associated with telomere length preservation. The effect was 6 years of length for 100 minutes a week and 9 years of advantage for 3 hrs or more.
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