Discerning between association and causation in telomere biology

Ed Park, MD dr ed park, stem cell theory of aging 0 Comments

Just a brief link to a study which really cuts to the core of what I believe to be the essential truth of aging and disease. That the erosion of telomeres in our stem cells is both a necessary and sufficient cause of disease formation for the changes we associate with aging.

When we were recently in Berlin, they boasted how the expatriate Albert Einstein taught at Humbolt University there. Another famous Humbolt scientist is honored by this statue we saw of Robert Koch, whose four postulates set the foundation for microbiology in 1884:

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  1. The microorganism must be found in abundance in all organisms suffering from the disease, but should not be found in healthy organisms.
  2. The microorganism must be isolated from a diseased organism and grown in pure culture.
  3. The cultured microorganism should cause disease when introduced into a healthy organism.
  4. The microorganism must be reisolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent.

When discussing causation in experimental science, the broader metric is the Bradford-Hill Criteria. I will plagiarize my own blog posting about this topic to bolster my stem cell theory of aging and disease:

“Telomere shortening causes aging!

I can make this statement but how do you objectively establish causation versus association?  In epidemiology, we use the NINE BRADFORD-HILL criteria, which represent common sense rules of logic.   The more of the criteria you have, the more likely something is actually CAUSING something else and not just associated.


Anyone can come up with a theory.  Here are some popular ones: the sun travels around the earth, gods roll dice to decide our destinies, evil spirits can cause madness.

By using the Nine Bradford-Hill criteria, we can assess causation for just about anything. Let’s say I have a theory that “having four wheels on a vehicle causes lethal motor vehicle accidents.” After all, almost all of the lethal MVA’s are associated with four-wheel vehicles. Intuition tells us this is association and not causation but let’s go through the process to show you how the criteria work:

STRENGTH –  good.  Most accidents involve cars with four wheels.
CONSISTENCY – again good, given most MVA’s involve passenger cars
SPECIFICITY    – poor.  Motorcycles and 18-wheelers are more lethal than four wheel accidents.
TEMPORALITY: fair. You usually need four-wheels to get into an MVA
GRADIENT: poor in either direction.  Fewer wheels (Motorcycles) and more wheels (trucks) are more lethal.
PLAUSABILITY: poor. Why would four wheels do this?
COHERENCE: poor. Why would four wheels do this?
EXPERIMENTAL EVIDENCE: poor.  NTSB tests have not been done comparing four wheels with two wheels because the outcome is obvious. Just ask any ER physician.
ANALOGY: poor.  Who is more nimble, you or your dog or cat? Four legs, like four wheels is a good foundation.

What about the theory that telomere shortening causing aging?

STRENGTH – excellent. The older you are, the shorter your telomeres. The fastest shortening comes with premature aging syndromes (Progerias)

CONSISTENCY – excellent. All humans age and all humans show telomere shortening as they age.

SPECIFICITY – excellent. Shortening telomeres are a hallmark most  of the Progerias

TEMPORALITY- good.  Shortening of telomeres occurs before aging appears

GRADIENT – excellent.  The older you get, the shorter they get

PLAUSABILITY – excellent.  Loss of protection of the ends of chromosomes allows for DNA rearrangement

COHERENCE – excellent. Loss of protection of the ends of chromosomes allows for DNA rearrangement and subsequent disease

EXPERIMENTAL EVIDENCE – Nature has done these experiments in the form of the Progerias which involve DNA repair deficiencies.

ANALOGY: excellent.  Telomeres protect the tips like aglets on shoelaces.  Another analogy is that aging chromosomes are like candles burning on both ends.”

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Ed Park, MD

I graduated from Harvard with honors in Biological Anthropology prior to earning my Medical Degree and Masters in Public Health from Columbia University.

In 2007, I became the nineteenth patient to sign up for the use of a herbally-extracted telomerase activator.

The results were so positive that I founded Recharge Biomedical Clinic in 2008 and have since become the leading medical expert in this exciting new field of regenerative medicine treating over 1,300 patients with this exciting new telomerase activation medicine.

I won two Houston Film Festival Awards for my screenplays about Hypatia of Alexandria and Ed Brown of Kentucky.

In 2010 I wrote and self-published a Sci-Fi Graphic Novel called MAXIMUM LIFESPAN

In 2013, I wrote and published "Telomere Timebombs; Defusing the Terror of Aging"

My websites are:
http://www.lokahi.guru (where you can learn about my RECHARGE adaptogenic supplement)
http://www.rechargebiomedical.com and

You can sign up for my weekly blogs on this page and subscribe to my YouTube videos at https://www.youtube.com/drpark65
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