If together, ATM kinase and p53 decide that the DNA is beyond repair, the cell will undergo apoptosis as orchestrated by p53.
someday we will have the precision tools to defeat it or let it run its course like a cold or flu in an immune competent host.
Telomere crisis results when the protective caps at the end of chromosomes, known as telomeres, become shortened as a result of cell divisions. With less DNA present in telomeres, it becomes harder to prevent separate chromosomes from attaching to each other. If those abnormal cells survive and continue to divide, they can give rise to cancer.
we discuss his amazing new book, The Telomerase Revolution, in which he explains why everyone with their pet theories and ideas about diet and what causes things from heart disease to Alzheimer’s, are all wrong.
This article from JAMA argues that the 4.8% cancer mortality rate for large and long-lived elephants compares favorably to our 25% rate because unlike our two copies of the p53 (watchman of the genome) gene, they have up to 40 copies.