What if the principle clock that truly matters is actually in the DNA of the cells of the hypothalamus?
Since 1960, Charles has owned a Siamese cat named “Blue”. The first three cats were good for over fifty years of companionship but this fourth “Blue” is an actual clone of Blue #3.
Over time, the dutiful and dysfunctional stem cells die off but others, like the Mafia capos or career politicians, become unable to kill themselves so they persist and cause problems while still lengthening their telomres.
Watch my fast-paced interview with Dr. Aubrey de Grey, Chief Science Officer of the SENS Research Foundation. SENS is the Strategies for Engineered Negligible Senescence.
In my search for wisdom about aging, I maintain that the primary cause is telomere shortening. This does not mean that methylation, signaling with stem cell produced vesicles (like packages with a purpose) don’t play a secondary role.