In my search for wisdom about aging, I maintain that the primary cause is telomere shortening. This does not mean that methylation, signaling with stem cell produced vesicles (like packages with a purpose) don’t play a secondary role.
A study out of Princeton looking at 1,567 9-yo children found that for each hour less than the recommended 9-11 hours of sleep, they averaged 1.5% shorter telomeres.
What if the stem cells, on a much slower level, are also undergoing gradual genetic mutations? That is the invisible elephant in the room.
they could “cure” their HGPS mouse model by two two things. In figure C, they added telomerase activity. In figure D, they added a little extra LAP2α.
There are many who feel that telomeres and telomerase are not centrally related to aging. This study shows that for at least this classic model of premature aging, Sutton’ Law still applies.
So in a sense, good health is like keeping a bathtub full of clean water. The supply of water is nearly endless if we can keep the mesenchymal stem cell library frozen in our cartilage from aging when recruited. And if we can drain out the foul water (mutated stem cells), then we are going to be just fine.
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