What if the stem cells, on a much slower level, are also undergoing gradual genetic mutations? That is the invisible elephant in the room.
they could “cure” their HGPS mouse model by two two things. In figure C, they added telomerase activity. In figure D, they added a little extra LAP2α.
There are many who feel that telomeres and telomerase are not centrally related to aging. This study shows that for at least this classic model of premature aging, Sutton’ Law still applies.
So in a sense, good health is like keeping a bathtub full of clean water. The supply of water is nearly endless if we can keep the mesenchymal stem cell library frozen in our cartilage from aging when recruited. And if we can drain out the foul water (mutated stem cells), then we are going to be just fine.
I received an email asking about this exciting breakthrough in understanding aging that could help us reverse it. It turns out it is none of the above. Good old Time magazine- sell the sizzle, swap the meat.
I believe that eventually the world will join me in understanding that there is really only one disease, with many faces. Depending on how long and in which organs the process has run, you see manifestations of disease and aging that you might call aging.