Over time, the dutiful and dysfunctional stem cells die off but others, like the Mafia capos or career politicians, become unable to kill themselves so they persist and cause problems while still lengthening their telomres.
A body is a machine in turn made up of trillions of cellular machines, all exhibiting decreasing genomic integrity and stability as we age. Here are some insights which help to explain aging as the result of increasing entropy
In this 62-minute, we have a cheerful and accessible discussion that nonetheless goes quite deeply into my Telomere/Stem Cell Theory of Aging- right down a breakdown of Koch’s Postulates (the foundation of establishing disease causation versus correlation), the nature of stem cells, and how to naturally live longer and healthier
“flow-FISH was more accurate, reproducible, sensitive, and specific in the measurement of human leukocyte’s telomere length in comparison to qPCR”
Instead of being thrown off the the trail by the differences, we should find the commonalities. Both models of aging- oxidative damage and telomere shortening cause chromosome disruption and bone marrow mesenchymal stem cell damage and depletion.