General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. The clinical use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition and may carry unknown risks. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and legally protected patient-physician relationship.
Exosomes 33: Reversal of Menopause
In this blog, I want to describe a fascinating case of resumption of menstruation in a 71-yo woman. The patient received 10B IV MSC exosomes and according to her, she “felt something happening in her ovaries” that same night. Since administration, she described two normal appearing menses which started heavy and tapered off. Her changes were associated with an increased in general nipple sensitivity. As a trained OB-GYN, I advised her consider the possibility of uterine hyperplasia and precancer and to get an endometrial biopsy.
Typically, post-menopausal bleeding occurs without hormonal changes such as premenstrual symptoms and begins as spotting. There can also be abnormal and prolonged bleeding depending on the endometrial conditions of atrophy, hypertrophy, or dysregulation. The patient is a naturopathic physician and states that the cramps, nature of flow and duration were typical for a non-pathological uterine menstruation.
In my experience, people taking telomerase activators do occasionally report resumed menses although it is not generally prolonged. The prevailing theory of menopause involves depletion and mutation of available ovarian follicle progenitor stem cells which have no way of replenishing from the time that their numbers are established in utero.
As I was revisiting the topic of menstrual function (which I first remember being asked to explain as a fifth grader), I was pleasantly surprised to find there is new information to the old model of ovarian hormone production and feedback to the hypothalamus and pituitary. That new information has been the subject of investigation for around ten years and has made it into the canon of acceptable knowledge. It is known as KISSPEPTIN.
Although the details are yet to be fully understood, it appears that both positive and negative feedback of sex hormones are mediated via hypothalamic cells that produce the protein known as Kisspeptin. Without going into all the details, suffice it to say that individuals with premature ovarian failure and dysfunction (including polycystic ovary syndrome) can have gene mutations or deletions of this important hormonal mediator. It is likely that the balance between the inhibitory and stimulatory effects of kisspeptin in response to estrogen and other neuropeptides influences the rhythm and amplitude of the secretion of pituitary hormones and the fact that supplementation with the protein can improve in vitro outcomes with reduced hyperstimulation of the ovaries points towards its central role in successful ovulation and reproduction.
I think the discovery of new and central players in what we once considered “settled science” illustrates an important principle: we don’t know what we don’t know and we certainly don’t look for it.
I am reminded of the limits of our knowledge daily since my son and I discussed his nasal congestion a couple of weeks ago. I mentioned that Ayurveda suggests that the breathing is preferentially via the right nostril when wanting to heat and through the left when needing to cool. My son put the fan on for 15 minutes and sure enough, his previously clogged left nostril breathing stopped and his right nostril breathing automatically replaced it. These days, just for fun, I check which nostril I am breathing out of and sure enough, it always reflects my own subjective temperature milieu. You can read more about it from this blog from 2014. Is this just confirmation bias or does it reflect a basic physiology that Western medicine doesn’t teach?
Why did I bring that up? Because when a person like my 71-yo patient tells me that she is menstruating again I have to hold the skepticism of my dogmatic medical training (everything gets worse with age) and I also have consider the possibility that some rescue of ovarian reserve or kisspeptin function in the hypothalamus was triggered.
That said, I have had around 20 exosome patients who were post-menopausal and the resumption of menstruation only occurred in one other patient that I know of and was not long-lasting. It should be noted that as naturopathic physician, this patient uses many therapies, including lifestyle practices to maintain a highly optimized state of health. The patient was advised to have the routine, worse-case presumption of ruling out endometrial hyperplasia and cancer but my mind is open to the possibility that cellular changes occurred that would allow such a thing to occur.
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Archived exosome blogs….Please read them all.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.