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Exosomes 33: Reversal of Menopause in a 71-yo woman

General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. The clinical use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition and may carry unknown risks. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and legally protected patient-physician relationship.

Exosomes 33: Reversal of Menopause

In this blog, I want to describe a fascinating case of resumption of menstruation in a 71-yo woman. The patient received 10B IV MSC exosomes and according to her, she “felt something happening in her ovaries” that same night. Since administration, she described two normal appearing menses which started heavy and tapered off. Her changes were associated with an increased in general nipple sensitivity. As a trained OB-GYN, I advised her consider the possibility of uterine hyperplasia and precancer and to get an endometrial biopsy. 

Typically, post-menopausal bleeding occurs without hormonal changes such as premenstrual symptoms and begins as spotting. There can also be abnormal and prolonged bleeding depending on the endometrial conditions of atrophy, hypertrophy, or dysregulation. The patient is a naturopathic physician and states that the cramps, nature of flow and duration were typical for a non-pathological uterine menstruation.

In my experience, people taking telomerase activators do occasionally report resumed menses although it is not generally prolonged. The prevailing theory of menopause involves depletion and mutation of available ovarian follicle progenitor stem cells which have no way of replenishing from the time that their numbers are established in utero. 

As I was revisiting the topic of menstrual function (which I first remember being asked to explain as a fifth grader), I was pleasantly surprised to find there is new information to the old model of ovarian hormone production and feedback to the hypothalamus and pituitary. That new information has been the subject of investigation for around ten years and has made it into the canon of acceptable knowledge. It is known as KISSPEPTIN. 

Although the details are yet to be fully understood, it appears that both positive and negative feedback of sex hormones are mediated via hypothalamic cells that produce the protein known as Kisspeptin. Without going into all the details, suffice it to say that individuals with premature ovarian failure and dysfunction (including polycystic ovary syndrome) can have gene mutations or deletions of this important hormonal mediator. It is likely that the balance between the inhibitory and stimulatory effects of kisspeptin in response to estrogen and other neuropeptides influences the rhythm and amplitude of the secretion of pituitary hormones and the fact that supplementation with the protein can improve in vitro outcomes with reduced hyperstimulation of the ovaries points towards its central role in successful ovulation and reproduction.

I think the discovery of new and central players in what we once considered “settled science” illustrates an important principle: we don’t know what we don’t know and we certainly don’t look for it.

I am reminded of the limits of our knowledge daily since my son and I discussed his nasal congestion a couple of weeks ago. I mentioned that Ayurveda suggests that the breathing is preferentially via the right nostril when wanting to heat and through the left when needing to cool. My son put the fan on for 15 minutes and sure enough, his previously clogged left nostril breathing stopped and his right nostril breathing automatically replaced it. These days, just for fun, I check which nostril I am breathing out of and sure enough, it always reflects my own subjective temperature milieu. You can read more about it from this blog from 2014. Is this just confirmation bias or does it reflect a basic physiology that Western medicine doesn’t teach?

Why did I bring that up? Because when a person like my 71-yo patient tells me that she is menstruating again I have to hold the skepticism of my dogmatic medical training (everything gets worse with age) and I also have consider the possibility that some rescue of ovarian reserve or kisspeptin function in the hypothalamus was triggered.

That said, I have had around 20 exosome patients who were post-menopausal and the resumption of menstruation only occurred in one other patient that I know of and was not long-lasting. It should be noted that as naturopathic physician, this patient uses many therapies, including lifestyle practices to maintain a highly optimized state of health. The patient was advised to have the routine, worse-case presumption of ruling out endometrial hyperplasia and cancer but my mind is open to the possibility that cellular changes occurred that would allow such a thing to occur.

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Archived exosome blogs….Please read them all.

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A nine-part comprehensive explanation of exosomes.

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66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.

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54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection

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I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.

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We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.



2 thoughts on “Exosomes 33: Reversal of Menopause in a 71-yo woman”

  1. More exciting anecdotal info about Kimera Labs MSCs derived exosomes! Thanks for sharing Dr. Park!

  2. Pingback: Exosomes 34: Double vision | Recharge Biomedical

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