General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.
Exosomes 29 – Are exosomes “smart”?
Today, I would like to borrow from one of my astute patients and use her phrase- little nanobots.
“Forgive me but it works like nanobots in sci-fi.”
Antonia from blog 7 and blog 27 took two treatments and she also described them as “little gods”.
Finally, I was just in Hawaii and speaking with a lady whom I had treated three months prior and she also noted changes in areas that were damaged in the remote past; it made her believe there was an intelligence to where they go.
The MSC cells that produce the exosomes are indeed agents with a kind of “intelligence” that would include sensation, reaction, docking, and signaling behaviors according the situation. They have agency and so can rightly anthropomorphize them and consider them to be nanobots or “little gods.”
MSCs are located in the vessels throughout the body and orchestrate healing by engraftment or transformation into needed specific stem cells types. They can also dock and directly inject material into other cells. Principally, we believe they work by releasing exosomes that, after docking with cells, will change behaviors, cell phenotype, and even modify the environments.
But exosomes that we are giving are decidedly NOT cells. They lack all the machinery of a cell such as a nucleus to reproduce themselves and they lack the endocytic pathways of endoplasmic reticulae needed produce and package proteins and mRNA. Exosomes are not musicians, they are the songs; they are phosopholipid spheres filled with better proteins and mRNA than the ones that you are making.
In the previous 28 blogs, we have described some amazing transformations including varicose veins disappearing in 10days (blog 28) and increased heart rate variability overnight (blog 2).
It is my best guess that there is minimal specificity although the roles of the surface proteins CD9, CD63, and CD81 are important in docking the exosomes to cells. Most likely, the exosomes dock and release their contents rather indiscriminately into any and all cells. If there is an area of inflammation, there may be relatively more blood flow and a higher likelihood of delivery although given their size, they go everywhere quickly and are equally consumed as quickly. This all implies that quantity, location, and dispersion are critically variables.
When a cell or organ is functioning close to normal, the results would not be noticeable. But in areas where there is ongoing inflammation or unresolved cellular damage or dysfunction, the effects can be impressive. Instead of being intelligent or purposeful, I believe it is more likely that down-regulation of inflammation, increasing of regenerative messages, and proliferation of new tissues are producing the “smart” effects.
Let me end by saying that not everyone has the same dramatic results and not everyone is satisfied although I put the percentage at around 85%. This means that 15% of patients did not notice improvement worth noting. None have gotten materially worse. Some of this may be recall and attribution bias as discussed in blog 21.
Why don’t exosomes work for everyone? One reason is that there was too much damage to be remediated with one treatment. Maybe we gave up too soon? Our pilot returned for a second treatment after a 65% improvement and now he says he is bench pressing 315lbs! See the carwash blog 24 for more on that.
Another problem may be that the degree of regeneration required dedifferentiation of a kind that is not available to adult cells; such primitive plasticity is more typical in a human embryo or regenerating salamander limb. Another reason might be that structures like nerve pathways lacked the scaffolding to make their end-to-end migrations as in the case of spinal injuries.
In my graphic novel, I hypothesized that someday we would have nanocytes to take “Fantastic Journeys” and repair cells on the cellular level. Although that might seem like an advancement, it would only amount to a very poor imitation of the existing smart robots we know as the immune system, mesenchymal stem cells, and local stem cells that are constantly protecting and regenerating us.
Now, with exosomes, we have the ability to get the cells back on track and playing the music of regeneration. The composer and scroll maker are no longer present so there is no intelligence at work in these static messages. But after the exosome reaches the living cells the receiving musicians start producing their own music according to the mRNA and siRNA (piano scrolls) that were transferred to them.
In conclusion, the exosomes are the music and the piano scrolls produced by master musicians but they bear a generic, not bespoke message of regeneration; the appearance of intelligence in their action is likely a stochastic artifact of them reaching many cells. A corollary to this non-specific delivery is that even though many cells do not appear to improve, they might be transformed into phenotypically “younger” versions of themselves and therefore be more resistant to manifest bad behaviors that we refer to aging and disease.
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Archived exosome blogs….Please read them all.
N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.