Today is day 15 after injection and for the first time in a long time, this 80-yo completed his 5.8mile run without stopping to walk due to knee pain. He is very happy!
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Exosomes 2: Not inert

General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition.  Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.

Exosomes 2: Not Inert

I have exciting news to report: exosomes are not inert!

INERT: adjective.

Pharmacologyhaving no pharmacological action, as the excipient of a pill.
I embarked upon this journey because MDs were reporting real improvement with joints and especially incurable central nervous system problems. The science of regeneration and MSC action was compelling. In order to be sure it was safe and I understood some of the effects, I took one IV treatement, two intranasal treatments, and injected my Achilles tendon, right knee joint, and right shoulder tendon. You can read more in my first blog with the password “parkblog”
My mother also began the journey with me two months ago and couldn’t be happier.
So what you all want to know is that it isn’t inert, not harmful, and potentially beneficial. Future blogs will explore those questions in depth.
But for this blog, I would like to explain why I don’t believe exosome therapy is inert. As mentioned, I still retain the ability to generate ASMR (goosebumps) and my sleep cycles and overall requirement are changed. Mom has consistently lower blood pressure. She feels so optimistic that she want to attend medical school at age 81; I had to tell her it was probably not going to happen.
Not Inert: Case 1
Two weeks ago, I opened the practice to our first patient, the amazing Doug Malewicki. I injected each of his knees with 4B exosomes. Interestingly, the onset of muscle cramps was delayed relative to mine; mine began on day 3, his began on day 4 and peaked twice: day 5 and 6, and then was worst on day 10. Today is day 15 after injection and for the first time in a long time, this 80-yo completed his 5.8mile run without stopping to walk due to knee pain. He is very happy with his performance.

Oddly, he no longer gets up several times a night to urinate. Finally, his day 10 muscle cramps that occurred in specific sites throughout the body were brief and severe and now have resolved. It would appear that some exosomes probably escaped from his knees and went to work in muscles (and possibly his prostate) far away from the site of injection.
Once an engineer, always an engineer. Here is Doug’s spreadsheet for his results until two days ago.
Doug Malewicki Leg Cramps Summary
2019 May Date Day Night Time Leg Cramps Comments
14 Tues 0 Injection Day
15 Wed 0  
16 Thur 0  
17 Fri 0  
18 Sat 5 These were all nasty lock up cramps on my right calf (outside right)
19 Sun 10 More normal minor cramps
20 Mon 10 More normal minor cramps. Lateral Dorsi however, was a bit stiff/tight even after my full abs work out
21 Tues 2 Less leg cramps. Lateral Dorsi (Right side only) hurt again.
22 Wed 0 All good
23 Thur 5 More normal minor cramps only
24 Fri 50 This was the awful, awful night!
25 Sat 5 More normal minor cramps plus one Charlie Horse above and real close to the top of my right knee cap.
26 Sun 0 Afternoon nap-had 1 small L calf cramp. Was over in 3 to 5 seconds. Was a nothing Lateral Dorsi day too.
27 Mon 0 Zero right Lateral Dorsi hurting/stiffness too.

Not Inert: Case 2

Two days after Doug was treated, another patient, an elite 60 yo athlete who has been taking GDF11 for 343 days. Two things are notable: at the site of his hamstring tendon injection, he has had cramps and “nodules” that massage out. They are not painful as much as tight and his exercise is not impaired. Secondly, he has been recording daily heart rate variability, which is an indicator of your overall health that you can learn about here.

Without knowing anything, you can probably see that something changed on day 344, the day after IV exosome injection, and has remained improved. The fourth column of RMSSD is the standardized measurement of heart rate variability and it changed for the better and has stayed qualitatively different. We can talk about placebo in the patient, but since I didn’t tell the patient to expect these changes, it definitely wasn’t the power of suggestion. Also, with the exception of Indian fakirs and trained actors, this measurement is hard to influence consciously. It is a function of your acidity, state of anxiety, and the health and youth of your nervous and circulatory systems. See this study of airline pilots to learn more about performance under stress and how HRV correlates.
I would venture to guess that persistent 22% increase in heart rate variability within 24 hours is attainable by absolutely nothing heretofore imagined or discovered.

As for the other three patients, I am learning so much from them as well which I will continue to share. Everyone felt some changes and whether those symptoms and changes represent general, specific, or indirect changes, I will need to gradually learn from experience and communication.
I have a multiple ligament injury patient coming in and also patients with head trauma and lumbar disc disease scheduled as well.
Stay tuned for more interesting observations and hopefully more encouraging changes. Of course, these are merely anecdotes and exosome therapy is not standard of care nor FDA-approved.
Postscript: the best part of talking to Doug today was the perceived ageist “microaggression” he received from some 60-something whippersnappers who called him “sir” as he passed them by. Too funny! He said he was running better than they were and where did they get off calling him “sir” unless they were ex-military.
That said, if you don’t think Doug has a sense of humor about aging, just consider that his favorite word to describe himself is “geezer.” If you don’t think ageism can be funny, read this recent blog.

Feel free to bookmark the following link to have all my exosomes videos at your fingertips!


Archived exosome blogs….Please read them all. 

N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.

I still have voluntary ASMR. Mom’s arthritis is greatly improved.

I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.

A case of whiplash and traumatic brain injury improved after exosome use.

After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)

In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.

Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.

A patient after dental exosome injection becomes pain free after 4 years of suffering.

I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.

A nine-part comprehensive explanation of exosomes.

I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes

66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.

80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.

My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.

54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection

48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently

I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.

Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy

Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy

We discuss the notion of energy centers known as chakras and the fact that we are electrical beings

A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.

I explain how poor we are at assessing change and how attribution and recall bias play important roles

In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.

I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation

I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.

I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.

I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.

Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).

Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.

I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.

I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.

I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.

We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.


14 thoughts on “Exosomes 2: Not inert”

  1. love these blogs. especially your Mom feeling so good she wants to go to medical school. when she hits 120 she may regret not going . Im thinking about it myself . Its a whole new world out there and finally were getting some real medicinal breakthroughs.

      1. yes, hes feeling much less pain and his spirits are great. hes very busy writing and teaching . hes a little tired at times, but much less than before . he should be tired with doing yard work and having the schedule of a 30 year old. his only complaint is he feels he needs his legs to be stronger still, but they are getting better and he has trouble not having something to grab on when going up stairs or uneven ground probably from all the old spine injuries and lyme stuff. hes also treating lyme with traditional chinese medicine doc in nyc. and that is also helping him. For the first time ever he really doesnt have all the aches and pains.
        as for me , i am feeling some flare ups of spine injuries and lyme stuff . i feel like its being worked on and my body is trying to repair things because its an up and down thing and its been since may 17th that i did 5 billion by iv

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