Exosomes 7: Nerve Pain Gone

Ed Park, MD anecdotes, dr ed park, exosome blog, exosomes 2 Comments

General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition.  Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.


Exosomes 7: Nerve Pain Gone

I would like to share an interesting case that shows the benefits of exosomes in a friend with neuralgia (nerve pain). Antonia is a 62-yo woman who underwent a dental procedure on her mandibular molars four years ago.

During the procedure, the instruments slipped and the jawbone and tongue were severely traumatized. For the last four years, she has had a severe pain and “tightness” which is not relieved by neuromodulatory medications. She was in such severe pain that she asked to have her molar teeth removed on the affected side only to find the the pain did not decrease and the teeth removed were perfectly healthy.

To deal with the chronic pain, the patient began to dedicate herself to weight lifting and intense workouts of martial arts. This had the benefit of strengthening her body, mind, and spirit and briefly providing endorphin-mediated pain relief.

Last week, she took 3.2B MSC-derived exosomes in the nerves supplying the lower jaw (the inferior alveolar nerve), 3.2B MSC-dervived exosomes intranasally, and 8B IV.

Within 24 hours, The pain she had endured for four years was completely gone and has remained gone for over a week. She elected to have another similar procedure before returning to Australia given the difficulty of travel and how wonderful she felt with regard to absence of pain, clarity of thought, and performance in the gym.

Of course, there are many explanations for this phenomenon. Firstly, the placebo effect mediating some as yet unlocked pathway of regeneration. Secondly, neuromodulation of pain signalers by decreasing inflammation locally and globally. Thirdly, apoptosis of nerves that were in crisis but unable to die (like a ‘live wire’ downed electrical line). Fourth, regeneration of nerves and/or their myelin sheaths by Schwann cells (like wrapping the live wires with electrical tape).  Fifth, any number of changes in protein expression made possibly by the messenger RNA, interfering miRNA, and proteins in the exosomes.

Regardless of the mechanisms at work (which probably involve all of the above), this patient is like the lion with the thorn removed from its paw. Life with chronic pain is a challenge that will not be ignored. I am happy to have helped facilitate a shift allowing her to focus elsewhere where it is needed.


Click on the image below to read a rather technical article showing how exosome use mitigated intentional injury to a mouse sciatic nerve.

 

 


Archived exosome blogs….Please read them all. 

N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.

 

https://www.rechargebiomedical.com/exosomes-1-the-journey-begins/

I still have voluntary ASMR. Mom’s arthritis is greatly improved. 

https://www.rechargebiomedical.com/exosomes-2-not-inert/

I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.

https://www.rechargebiomedical.com/exosomes-3-a-case-of-brain-and-neck-trauma/

A case of whiplash and traumatic brain injury improved after exosome use.

https://www.rechargebiomedical.com/exosomes-4-back-on-the-treadmill-again/

After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)

https://www.rechargebiomedical.com/exosomes-5-clinical-medicine-is-bittersweet/

In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.  

https://www.rechargebiomedical.com/exosomes-blog-6-healing-takes-time/

Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.

https://www.rechargebiomedical.com/exosomes-blog-7-nerve-pain-gone/

A patient after dental exosome injection becomes pain free after 4 years of suffering.

http://www.rechargebiomedical.com/exosomes-blog-8-disinformation-or-bad-science/

I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.

https://www.rechargebiomedical.com/exosomes-blog-9-watch-all-my-exosome-videos/

A nine-part comprehensive explanation of exosomes.

https://www.rechargebiomedical.com/interviews-with-exosome-experts-posted/

I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes

https://www.rechargebiomedical.com/exosomes-blog-11-deb-bs-knees-are-improving

66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.

https://www.rechargebiomedical.com/80-yo-doug-ran-121-miles-in-6-days/

80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.

https://www.rechargebiomedical.com/exosome-blog-13-microneedling-my-mom-with-exosomes/

My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.

https://www.rechargebiomedical.com/exosome-blog-14-the-shoulder/

54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection

https://www.rechargebiomedical.com/exosomes-blog-15-face-blindness/

48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently

https://www.rechargebiomedical.com/exosomes-blog-16-lecture-in-hawaii/

I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications. 

https://www.rechargebiomedical.com/exosomes-blog-17-reading-is-fundamental

Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy

https://www.rechargebiomedical.com/exosomes-blog-18-dental-health-improved

Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy

https://www.rechargebiomedical.com/exosomes-19-chakra-balancing-with-exosomes/

We discuss the notion of energy centers known as chakras and the fact that we are electrical beings

https://www.rechargebiomedical.com/exosomes-blog-20-seborrheoic-dermatitis/

A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.

https://www.rechargebiomedical.com/exosomes-blog-21-bias-is-unavoidable/

I explain how poor we are at assessing change and how attribution and recall bias play important roles

https://www.rechargebiomedical.com/exosomes-22-badpress/

In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.

https://www.rechargebiomedical.com/exosomes-blog-23-stasis-dermatitis

I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation

https://www.rechargebiomedical.com/exosomes-blog-24-how-long-do-exosomes-last

I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.

https://www.rechargebiomedical.com/exosomes-blog-25-knee-treatments/

I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.

https://www.rechargebiomedical.com/exosomes-blog-26-the-placebo-effect/

I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.

https://www.rechargebiomedical.com/exosomes-27-soft-signs-of-exosome-actions/

Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).

https://www.rechargebiomedical.com/exosomes-28-varicose-veins/

Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.

https://www.rechargebiomedical.com/exosomes-29-are-exosomes-smart/

I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.

https://www.rechargebiomedical.com/exosomes-30-real-exosomes-patients/

I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.

https://www.rechargebiomedical.com/exosomes-blog-31-leg-swelling/

I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.

https://www.rechargebiomedical.com/exosomes-32-nerve-regeneration

We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.

 

Comments 2

  1. Thanks for sharing another amazing exosomes story. I’m glad you were able to help Antonia and hope you can continue to help those in need.

  2. Pingback: Exosomes 36: Tinnitus | Recharge Biomedical

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