General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.
Exosomes 21: Bias is unavoidable
I would like to discuss two types of bias: recall bias and attribution bias. As you know bias is merely prejudging and in fact, as I discussed in blog 15 below about face blindness, “without biased thinking I would have no thinking at all.”
In areas of social identity, people resist bias although it is unavoidable as an artifact of cognition. In fact, the inability to see things like sex, age, gender, and perceived ethnicity would make you unable to function in a world of very sensitive people.
I would like to use several cases of changes associated with clinical exosome use to illustrate how important recall and attribution bias are to clinical patient satisfaction.
I had the pleasure of treating my friend with prosopagnosia and spoke with her a couple of days ago. I asked her how things were going and she said there was an example of face blindness that discouraged her. Upon further discussion, her recall bias of comparing her current state to before she was affected instead of the last 14 years again surfaced. She ran into a woman whom she should have known and was ashamed to not remember her face; but as she and I were speaking she could now picture her face. Since the original meeting occurred before treatment, it was never memorized. Days later, she could now picture the woman’s face proving that the her condition of memorizing NEW faces is better.
The second case is my friend Doug who is the subject of blog 12 below, who received a second knee treatment this week. As discussed previously, this has been a banner year for his running and although he is reaching new heights in his athletic performance due to the absence of knee pain, he wasn’t sure the exosomes had helped. Objectively, he is at the peak of his performance the the fact that he actually returned this week for a second injection tells me that he recognizes the benefits. He ran 7 miles the day of treatment and a half-marathon yesterday.
In the case of side-sleeping with rotator cuff injuries, I admit to being guilty of faulty attribution bias. I had a tear and before exosomes, I couldn’t sleep on my right side. Now I can. My patient with the fractured scapula immediately recognized this change because the pain was so severe and the ability to side sleep was immediate. Mom also noticed this. But I had a 84-yo woman who hasn’t slept on her side for 4 years and when that ability returned after subacromial exosome injection she simply shrugged (pun intended) that she knew it would come back eventually, attributing none of the benefit to the injection!
I think attribution bias is a complex phenomenon related to recall bias; we compare everything with how we felt when we were young because in our minds, we are all still 18-years old. Another huge factor is how much you paid for the treatment. If you paid a lot, ironically, you attribute much of the benefit to treatment. If you receive a complimentary or low cost treatment, you tend to not attribute any benefit to the exosomes as a subconscious protection from indebtedness and for fear of needing the to pay for improvement in the future.
I leave you with a final case where recall and attribution bias are completely impossible. I treated a 45-yo man with a spinal cord injury of ASIA class D (no sensation or movement) below T4 (nipple level). Every day, he is reminded not of being an 18-yo but that he can neither feel nor move anything below the level of his breasts. We performed a 6B MSC exosome injection into his lumbar spinal space and tilted him head down. Within a week, he was producing some movement in his abdomen, he felt pain in his abdomen, and his foot was responding to tickling with some reflex movements. I hope to blog more about his improvements in the future but for now I will say that unless you are severely affected like he is, the ability to be a reliable historian and judge of any changes after exosome therapy is a challenge for nearly everyone.
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Archived exosome blogs….Please read them all.
N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.
5 thoughts on “Exosomes 21: Bias is unavoidable”
In day to day living, biases can be very good. Being biased about a child’s potential can get them through some of the rough patches of growing up. The parent, too. We need to have healthy biases, positive ones, with our spouses. We can be either glass is half full people or glass is half empty people. We need to choose our biases well and take good care of them. In health, the placebo effect is awesome! Being sure things are going to get better certainly helps the outcome. That’s a good bias. I’m certain there’s a bit of placebo effect going on in exosome therapy, and that’s a GOOD thing! But the underpinnings are astounding! In years to come, it will become an adjunct to surgery. Miracles will happen!
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