Of all the treatments I do, I believe exosome treatment of knees are the easiest, least painful, and most effective.
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Exosomes 25: Knee treatments

General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition.  Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.

Exosomes 25: Knee treatments

Of all the treatments, it appears that the knees have the highest satisfaction rate, even in older people with advanced osteoarthritis.

Of course as a subscriber, you already know about elite 80-yo runner Doug, who is featured in blogs 12 and 21 below and about 66-yo Deb who is the subject of blog 11 and still doing 100 squats a day after not being able to do one.  But you have yet to hear that while I was in Hawaii, I also treated four other patients’ knees with great success. Allow me to share their experiences.

The first was a 80-yo man with severe pain due to osteoarthritis who had knee replacement recommended to him. On 11/18/19 he underwent bilateral knee injection with a total of 6B MSC exosomes and 3cc of Duralane hylauronic acid. The first night was very painful and I recommended anti-inflammatory pills (unlike with the desired inflammation after using PRP/Prolotherapy).  Around 10 days later, I got this text from his wife: “His legs are doing wonderful. I think he forgot that at one time he almost couldn’t walk. By this time he would have been having a knee operation.  Thank you.”

The second patient was a 66-yo man with recent knee injury about a month prior and moderate pain. He is the topic of blog 20 below regarding seborrheoic dermatitis. He also received 5B exosomes with 3ml of Durolane divided into both knees. He wrote to me on day 19:My knee is almost back to normal as in like-it-never-happened condition.” 

The third patient is a 60-yo martial artist and athlete with chronic knee pain scheduled to do “stem cell” treatment on his knees. He has done 1000 lb squats for years resulting in pain. He elected to do 6B MSC exosomes and 3ml Durolane into the left knee. Four days after treatment he reported the treated side felt like new.

The fourth patient is a very active 67-yo and athletic man with Left> Right knee pain for years. He had pain when squatting and getting up from accessing the bottom refrigerator drawer which he calls “his refrigerator test”. I will summarize his results but you can read unredacted and superb clinical notes below in full.  I wish all my patients gave me such detailed notes!

I think the notable findings are that like the first patient, the chronic OA began to improve about 10 days after treatment despite initial worsening and pain. His Baker’s cyst is a bursa which is filled with fluid from the osteoarthritic knee joint leaking backwards between the calf muscles. That Baker’s cyst pain and the knee pain on the left improved so much that the painful knee is now better than the right (which I recommended he also treat but he declined).

The most interesting thing is that there is still active remodeling going on by the clicking reports. It is very important that he not re-injure the knee during this time and we hope that the hyaluronic acid is providing a matrix for new cartilage creation.

What many people don’t appreciate is that total knee replacement is does not guarantee pain relief. A study of patients at the NY Hospital for Special Surgery showed that nearly 40% of patients had chronic pain of 3/10 a year after replacement.  If you have a chance of delaying or obviating total knee replacement, then that would be a good thing, right?  Of all the treatments I do, I believe exosome treatment of knees are the easiest, least painful, and most effective. While much of the symptomatic improvement may be attributable to the hyaluronic acid, keep in mind that our star patient, 80-yo runner Doug received only exosomes as this was before I developed my technique of combining them with the Durolane. If you want to learn more about the context in which this revolutionary technology appears, please watch this video explains the now obsolete methods of musculoskeletal regeneration:



FROM day 20 after treatment of Left knee only:

Small changes in the first week. Day 11 had the most change. Steady improvement thereafter to date. Started light exercise on Day 14 with slight swelling and weakness felt in knees. Looking forward to increasing the load on the knee joint as it improves. Wondering whether improvement due to hyaluronic acid or rebuilding of knee joint?

Day 2. 11/18/2019 (Monday) Morning. No noticeable improvement. Tenderness behind the knee. Knee and calf swollen. Pain from what feels like a small hard rubber ball (Baker’s cyst?) behind the knee joint creating pressure on the nerve. Refrigerator test (standing up from bottom drawer): pain in left knee may be slightly better but still cannot squat on knees due to left knee pain – pain #9 (scale of #1 -10. #1 being no pain) when trying to bend knee.

        -Took 2 Recharge capsules after breakfast.

-Evening/night. No noticeable improvement. Tenderness behind the knee. Knee and calf swollen. Continued pain from Baker’s cyst(?) behind the knee joint creating pressure on the nerve when squatting on knees. Lay on back on floor with raised left leg on chair for about 1.5 hours.

Day 3. 11/19/2019 (Tuesday) Morning. Slight but noticeable improvement. Less tenderness behind the knee. Knee and calf swelling is still there but reduced. Pain from Baker’s cyst (?) behind the knee joint creating pressure on the nerve is reduced. Refrigerator test: pain in left knee is better: pain #7 when squatting on knees. Less pain when standing up.

        -Took 2 Recharge capsules after breakfast.

-Evening/night.  Took 2 Recharge capsules after dinner.

Day 8. 11/24/2019 (Sunday) Morning. Slight but noticeable improvement. Less tenderness behind the knee. Knee and calf swelling gone but tightness around the joint. Pain from Baker’s cyst (?) behind the knee joint creating pressure on the nerve is greatly reduced. Refrigerator test: pain in left knee is better: pain #3 when squatting on knees. Less pain when standing up.

        -Took 4 Recharge capsules after dinner.

Day 11. 11/27/2019 (Wednesday) Morning. Noticeable improvement. No tenderness behind the knee. Knee and calf still tight. Pain from Baker’s cyst (?) behind the knee joint is about 98% gone. Refrigerator test: pain in left knee is much better: pain #0.5 when squatting on knees. Almost no pain when standing up but can hear knee joint “creek”.

        -Took 3 Recharge capsules after dinner.

FROM 35 days after Left knee treatment: 

Yes, I am doing well. Most of the pain is gone but still have the “creaking” noise from my left knee when standing up. Interestingly, my left knee  feels better than my right knee when standing up. However, the left knee still has some pain when doing trunk twisting motions – right knee no pain during the twists.

The other interesting thing is, although the sitting/standing pain is pretty much gone in my left knee, I still sub-consciously anticipate the pain whenever I initiate the movements. I guess it is the years of having to deal with the pain that has me conditioned.   

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Archived exosome blogs….Please read them all. 

N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.


I still have voluntary ASMR. Mom’s arthritis is greatly improved. 


I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.


A case of whiplash and traumatic brain injury improved after exosome use.


After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)


In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.  


Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.


A patient after dental exosome injection becomes pain free after 4 years of suffering.


I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.


A nine-part comprehensive explanation of exosomes.


I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes


66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.


80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.


My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.


54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection


48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently


I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications. 


Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy


Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy


We discuss the notion of energy centers known as chakras and the fact that we are electrical beings


A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.


I explain how poor we are at assessing change and how attribution and recall bias play important roles


In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.


I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation


I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.


I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.


I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.


Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).


Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.


I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.


I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.


I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.


We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.



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