Just a brief video showing an illustration of how telomerase works. I don’t believe there is an “End replication problem” as such because you want the non-stem cell ends to erode in the less valuable, differentiated and mortal cells. They are like drone bees that last months, unlike the queen bee stem cells which last years.
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Telomere depletion in primary stem cells or rather lack of regeneration per division or somewhere in time(telomerase activity initiation)would be the atomic/molecular glitch.