The fact that progeria-affected kids have undeniable biological aging despite young epigenetic and chronological ages implies that telomerpathies that drive them are still the most robust explanation for aging globally
Since 1960, Charles has owned a Siamese cat named “Blue”. The first three cats were good for over fifty years of companionship but this fourth “Blue” is an actual clone of Blue #3.
Over time, the dutiful and dysfunctional stem cells die off but others, like the Mafia capos or career politicians, become unable to kill themselves so they persist and cause problems while still lengthening their telomres.
A study out of Princeton looking at 1,567 9-yo children found that for each hour less than the recommended 9-11 hours of sleep, they averaged 1.5% shorter telomeres.
When we discuss the risk of telomere length to cancer risk, there are many studies but the conclusions we reach are limited by our simplistic assumptions.