My stem cell/telomere theory of aging and disease is a necessary and sufficient explanation for nearly every disease you can imagine
Cancer is common, fragile, curable by cell suicide or immune surveillance, and most associated with aging.
How telomere erosion leads to chromosomal mutation, which causes dysfunction and cell death (we hope)
Dying young but with perfect babies is sustainable and advantaged; dying old but with abnormal babies is an evolutionary dead end.
The fact that progeria-affected kids have undeniable biological aging despite young epigenetic and chronological ages implies that telomerpathies that drive them are still the most robust explanation for aging globally