How telomere erosion leads to chromosomal mutation, which causes dysfunction and cell death (we hope)
Failure to faithfully replicate and preserve stem cell DNA appears to be the final common pathway to premature aging
The fact that progeria-affected kids have undeniable biological aging despite young epigenetic and chronological ages implies that telomerpathies that drive them are still the most robust explanation for aging globally
What if the principle clock that truly matters is actually in the DNA of the cells of the hypothalamus?
A body is a machine in turn made up of trillions of cellular machines, all exhibiting decreasing genomic integrity and stability as we age. Here are some insights which help to explain aging as the result of increasing entropy