A study out of Princeton looking at 1,567 9-yo children found that for each hour less than the recommended 9-11 hours of sleep, they averaged 1.5% shorter telomeres.
Perhaps the better disease paradigm is that the ongoing clearance of bad cells and waste is a result of the evolutionary elegant design of the blood-brain barrier, which keeps the younger, more capable bone marrow-derived immune cells from entering this space.
Anderson et al showed a significant association with shorter telomeres and risk of dementia and mortality. But they call for more research and decline to state the two are causally related.
Here is an article linking shorter telomeres in the hippocampal region with Alzheimer’s.
This is the latest study linking shorter telomeres to disease (there are over 10,000) that once again falls victim to proving obvious yet useless information. In this study, they linked smaller hippocampal volumes (seen in Alzheimer’s) with shorter white blood cell telomeres in a subset of women with a genetic prediliction for Alzheimers (the abnormal ApoE3 gene).