When I’m asked about experts’ opinions, I think of a Bob Dylan lyric: “Don’t follow leaders; watch the parkin’ meters.”
A study out of Princeton looking at 1,567 9-yo children found that for each hour less than the recommended 9-11 hours of sleep, they averaged 1.5% shorter telomeres.
Perhaps the better disease paradigm is that the ongoing clearance of bad cells and waste is a result of the evolutionary elegant design of the blood-brain barrier, which keeps the younger, more capable bone marrow-derived immune cells from entering this space.
Anderson et al showed a significant association with shorter telomeres and risk of dementia and mortality. But they call for more research and decline to state the two are causally related.
Here is an article linking shorter telomeres in the hippocampal region with Alzheimer’s.
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