Are your naïve T-cells more like Martin Riggs or Roger Murtaugh?

Ed Park, MD dr ed park, immune senescence, stem cells, Telomerase activation, Telomere erosion Leave a Comment

Interestingly, Naive T-Cells can be further subdivided into “good cops” and “bad cops” as in Lethal Weapon. The good ones, present in younger, healthier individuals, are naive and ready to go, like Bat-guano crazy Mel Gibson’s Martin Riggs character. The bad ones are like Danny Glover’s character, Roger Murtaugh, hiking up their pants and counting the days to retirement while muttering “I’m too old for this $h!t”

CMV robs us of our youth in two nefarious ways

Ed Park, MD dr ed park, immune senescence, TA-65, Telomerase activation Leave a Comment

So we suspected that chronic CMV infection ages us but we only conprehended that the immune system burns out fighting it. Until this paper, we didn’t realize that it also steals the healthy gene transciption factors that the host cell needs to stabilize its telomers. It’s a double whammy.