General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.
Exosomes 24: How long do exosomes last?
For this blog, I would like to address the question I frequently get: “how long do exosomes last?”
When you think of it is is a really hard question to address as it takes into account a lot of unknown variables.
Let me explain by using an analogous question: “how long does a car wash last”
If you wash an undamaged car really well and then garage it without driving in a dustless vacuum chamber away from the sun, the car will stay pretty clean for a really long time. If you have a really filthy car and give it a wash it may ever get completely clean. And if your car has paint damage and rust then it may not look at all good, ever.
Similarly, if you are like Doug, the 80-yo extreme runner (see blog 12) who received knee injections and then put thousands of miles of wear onto his knees before his second unilateral injection, you can’t really say his treatment didn’t “last” when there was ongoing new damage.
If you are like our 44-yo paraplegic patient who is now having some new sensation and toe movement six weeks after exosome treatment, you don’t expect a full recovery from one “wash” because of the severe global damage to the incredibly complex spinal cord and its neurons.
And if you are like our overweight patient on her feet all day with knees that were so devoid of cartilage that her surgeon described it as “a mortar and pestle” then perhaps one exosome treatment was never going to repair the paint damage and rust that occurred.
On the other hand, I do receive a lot of reports from stem cell patients, some who took autologous and some who took homologous (off the shelf) stem cells that their treatments only “lasted” six months. Again, the same principles apply insofar as the degree of preexisting damage, ongoing accrual of damage, and efficacy of the treatment are all factors to consider.
If you were to ask me “how long do exosome treatments last?” I would have to reply “it depends.” In a relatively stable and low turnover organ like the brain, the treatment like the patient with prosopagnosia (face blindness) or the general improvements in reading and memory may last a very long time. I still have voluntary piloerection and shorter sleep cycles and my Achilles’, knee, and shoulder are pain free after injections but I don’t re-injure them with exercise like my patient with the shoulder injection in exosome blog 14 below.
In the case of severely damaged joints with ongoing damage, the answer may be that the improvement was permanent but inadequate to maintain a symptom-free state for long. But keep in mind that like the Jet Blue pilot who was wise enough to have a repeat treatment one month after his 65% improvement, if you do a better “cleaning” then you may be front-loading the duration of improvement by doing a better job of getting the car clean to begin with.
In conclusion, if you have an exosome treatment and there is substantial improvement, it is possible that you may want to do a repeat treatment soon after to “get the car as clean as possible”.
I close with the case of a patient who recently called me a month after his shoulder treatment. Initially, he experienced dramatic improvement allowing him to sleep on his side for the first time in four months. Unconsciously, he has been side sleeping and possible incurring new damage to his rotator cuff. Perhaps if he can’t avoid creating ongoing damage, he should consider a repeat treatment to get this shoulder a bit cleaner so that his treatment will last longer.
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Archived exosome blogs….Please read them all.
N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.