General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.
Exosomes 32 – Nerve Regeneration
RM is a 65yo man with no significant medical history who requested exosome treatment for nerve damage. He had done extensive research and consulted with experts and concluded there was simply no other treatment out there. Based on my experience with Antonia’s overnight nerve damage resolution (see blog 7), I agreed to try it.
Approximately 2.5 years ago, he was doing refurbishing with a degreasing agent from Home Depot. This solvent got soaked into socks and boots for hours and this resulted in a loss of fine touch in the soles of his feet. He stated it felt as though his feel were always covered in Saran Wrap. Interestingly, he retained pain, temperature, and pressure sensation as well as proprioception. No cognitive changes were noted.
Four weeks after that incident he was working with high vibratory power saw with left/dominant hand. This resulted in permanent numbness of the tips of the left first three digits.
The physical exam showed slight decrease in sensation in both soles and the first three digits of the left hand but no skin changes or motor/reflex dysfunction.
We proceeded with injection of 3B MSC exosomes into left median nerve using real time ultrasound guidance with excellent distention of nerve sheath.
Both sural nerves were infiltrated with 1B exosomes using anatomical landmarks. Both posterior tibial nerves identified with ultrasound and injected with 2.5B MSC exosomes each with excellent nerve sheath engorgement.
Within 12 hours, the sensation returned in the first two fingers of his left hands and he experienced dramatic improvement of fine touch sensation in his feet. Since then, he has continued to improve daily. Now, at two weeks, he texted me that his left middle finger is back to 8.5 out of 10, the left index finger is 9.5 of 10, and the thumb is totally normal. The soles of his feet are back to 6-7 out of 10 from being around 1-2 for fine touch prior to the procedure.
So why did these dramatic, immediate, and progressive improvements happen? Of course, it could be a placebo effect although this seems unlikely. Before we discuss what fixed it, we should discuss what caused it.
In the hairless skin of the fingers and soles there are many types of nerves and it is fascinating that the nerves for pain and temperature as well as the ones for pressure and were not damaged. In the soles of his feet, the cells destroyed were those responsible for fine touch are called Meissner corpuscles. There are also 1) free nerve endings responsible for detecting pain and temperature 2) Pacinian corpuscles for detection of vibrations and textures 3) Ruffini’s corpuscles for detection of light pressure 4) Merkel’s disks for shape determination.
So it appears that only the Meissner corpuscles on the soles were damaged by the solvent. This structure is derived from Schwann cells, which produce myelin. It is possible that the degreaser melted the fatty myelin sheath leading to the structure. The normal nerve loses its myelin before entering the corpuscle. It is possible that too much of the sheath was melted and it is possible that the restoration of the Schwann cells encouraged them to begin remyelinating those nerve endings.
When it comes to the left hand, the degreaser, like other fat soluble substances that accumulate in fat cells, could have lingered and contributed to the nerve damage that occurred four weeks later. The patient doesn’t recognize and cognitive impairment from this chemical exposure. It appears that the vibrations resulted in permanent median nerve damage. The injection of exosomes directly into the median nerve sheath may have allowed for remyelation or neuronal regeneration. The agents responsible for this may include BDNF (brain-derived neurotrophic factor) and GDNF (glial-derived neurotrophic factor).
In conclusion, I used to feel bad when treating patients didn’t completely cure them with one round of exosomes. But then I asked myself, would a higher dose have guaranteed total cure? Not necessarily. Secondly, is there any other treatment that can even make a difference? No. So if you have an 80% improvement in a condition that has no cure and may require a second treatment, I would now consider that a very good value proposition, wouldn’t you? I can tell you that this patient is very happy and would be willing to take another treatment now that he knows it works for him. It is a joy and privilege to practice the kind of medicine that can actually fix things, not just manage the damage.
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Archived exosome blogs….Please read them all.
N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.