General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.
Exosomes 14: The shoulder
This week I would like to discuss the shoulder joint. I received a text from my patient tonight who received an injection only four days ago: “Ok you have me very excited. I went to the gym to test my bad shoulder that you injected. It is now better than my good shoulder. At least 90% improvement so far”
He is a 54-yo man with 3 years of pain related to weight lifting and a tear in his rotator cuff which upon clinical exam was isolated to the subscapularis muscle.
Using direct ultrasound visualization, I was able to introduce 2.5cc of MSC exosomes mixed with Durolane hyaluronic acid directly into the bursa. I could actually see the fluid entering below the deltoid and above the rotator cuff. The other 2.5cc were injected into the lumbar epidural space and the patient was tilted head down to access his cervical disk areas.
The proper localization of the exosomes is critical as they can be wasted in the wrong space and the injection is painful when placed blindly into the muscles. The use of hylaronic acid is keep the exosomes in the local area to be absorbed by the required cells. Otherwise, they can be eaten up and carried away from the site of potential repair. The fact that the patient is an avid weight lifter is helpful because local stress and injury I believe activates the regenerative processes.
I would be remiss to suggest that everyone has experienced the same degree of success. My own shoulder and that of my mother are greatly improved but one of my patients in his 8th decade (with a lifetime of high-contact rugby) was unable to avoid shoulder replacement. On the positive side, I also have a 47-yo airline pilot patient that required two sessions to reach total repair. He stated being 65% better after one treatment and 95% after the second injection four weeks later. After a fall snowboarding in March, his body was not able to repair the rotator cuff. After not being able to lift his arm without pain, he is now helping to lift carry on luggage and is back to playing tennis! Another satisfied customer…
The shoulder is a particularly easy area to injure but also one that is very safely accessed by a posterior approach using palpation of landmarks and aided by ultrasound. The course I took on ultrasound-guided joint injections was so helpful and I feel quite confident injecting shoulders, knees, and hips alike.
When we consider why some joints never repair, the problems is that when we are older, the remaining stem cells in the muscles, tendons, and joints are depleted in their ability to repair by virtue of senescence (possibly from telomere erosion and epigenetic silencing). The introduction of MSC stem cell exosomes is a game-changer, allowing the local stem cells to be reactivated or allowing new ones to be recruited.
POSTSCRIPT: For my friends in Hawaii, I am happy to announce that I was approved to practice medicine in Hawaii. If you are interested in discussing a possible treatment on my next trip to Honolulu, please contact me at firstname.lastname@example.org
Feel free to bookmark the following link to have all my exosomes videos at your fingertips!
Archived exosome blogs….Please read them all.
N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.