General Disclaimer: This blog is for informational purposes only. It is not an advertisement for exosomes. Use of exosomes has not been FDA-approved for prevention nor treatment of any disease condition. Anecdotes provided do not constitute scientific proof and all patients were treated in the context of a fully informed consent and patient-physician relationship.
Exosomes 23: Stasis Dermatitis
Eczema is a common term for dermatitis but there are many types of this as defined by origin. The kind of dermatitis that I have is hereditary, known as atopic dermatitis, and appears in childhood with typical lesions in the creases of the elbows and knees as well as the neck. Scientists are divided as to what causes it but it is probably a variant of “normal” like psoriasis. The other forms of dermatitis include allergic and irritant caused dermatitis as would occur with contact with dust mites or detergents respectively. Today, I would like to show a case of the fourth kind of dermatitis known as stasis dermatitis.
The patient is an 86-yo woman who developed an itchy rash on both of her legs a few years ago. She did not have it as an adult or child.
Her dermatologist attempted to treat it with various topical steroid creams but it did not improve. When I first saw her, both her feet were extremely swollen and purple. It was to the point that if you pressed on the skin, it would indent a full centimeter. I didn’t take a picture at the time but it was quite severe and she had also developed a severe antecubital (elbow crease) rash after taking Recharge supplement, which I believe is an allergic reaction, not related to the venous insufficiency/stasis causing her leg rash.
She received 5B IV exosomes six weeks ago and when I saw her four days later, the feet were no longer swollen and looked like this.
Of note, her rash on the legs was still present and they looked like this on day 4 when she received another 4B exosomes in the lumbar epidural space and 2B exosomes + Hyaluronic acid (into her shoulder).
The patient went to the dermatologist to get some betamethasone steroid cream which helped the rash on the elbow creases. But the creams never helped the legs. I believe the exosomes, by improving her venous circulation, allowed the dermatitis to disappear. Here are her arms and legs only six weeks after her two treatments with exosomes.
I believe the dermatitis in her arms was different from the legs and that the improved circulation was the main factor in clearing her rash in the latter area.
As for myself, you might think that a shift from Th1 to Th2 t-cell type would cause an increase in dermatitis because typically atopic dermatitis is considered to be a shift in that direction. Actually my eczema always improves after a shot suggesting that the model is more complex and involves an improvement upon the dysregulation of the immune system.
Anecdotally, my colleagues report excellent results with mast cell classical allergic or “atopic” conditions of which asthma and “hay fever” also are a part of. The immune system is a very complex and dynamic system and whatever is occurring in the lymphocytes to alter their behavior may be more complex that just a simple shift of the Th1 and Th2 activity.
As with many things, younger is better and it appears that exosomes from young exosomes may have helped the venous stasis and resultant dermatitis in this patient. The possible mechanisms include rejuvenation of her veins and their valves, improvement of lymphatic drainage, and better cardiac function. Of note, her shoulder is much improved and she is able to sleep on it again.
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Archived exosome blogs….Please read them all.
N.B. On 2/29/2020 I changed my philosophy about keeping these blogs private. The archives up to blog 32 were appended to blogs that had yet to be created when the earlier ones were first written.
I still have voluntary ASMR. Mom’s arthritis is greatly improved.
I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.
A case of whiplash and traumatic brain injury improved after exosome use.
After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)
In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.
Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.
A patient after dental exosome injection becomes pain free after 4 years of suffering.
I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.
A nine-part comprehensive explanation of exosomes.
I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes
66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.
80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.
My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.
54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection
48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently
I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.
Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy
Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy
We discuss the notion of energy centers known as chakras and the fact that we are electrical beings
A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.
I explain how poor we are at assessing change and how attribution and recall bias play important roles
In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.
I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation
I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.
I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.
I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.
Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).
Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.
I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.
I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.
I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.
We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.