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Exosomes 39: The delayed reactions


For our 39th blog, I want to talk about delayed reactions. This blog was initiated be a phone call from one of the patients who recognized their initials on the 37th blog about my first year’s results. He felt bad that he left me with the impression that his knees were no better. In fact, they were much better! You can listen to our call here:


Interestingly, three of the ten patients who were on the “no response” list should be taken off making the adjusted response rate of 92%. I spoke with SR and he said there was some improvement and VC improved after several months (which he attributed to a steroid injection, although those effects tend to be fleeting and not regenerative).

I confess that with some cases (often nerves) improving overnight as in blogs 7, 32, and 38, I have gotten used to a rapid time course. In most patients, the effects are felt within the first two weeks if not sooner…so why did Sam not achieve pain relief until six months?

Perhaps the remodeling and regeneration is delayed in older patients because the epigenetic gene silencing makes the cells resistant to the message? Perhaps there needs to be recruitment of outside stem cells that takes time? Perhaps the remodeling is a process, not a quick fix…like making a butterfly from a caterpillar egg.

No news was good news for Vince

Vince is a very athletic 57yo actor who had shoulder, knee, and wrist injections in November of 2019. Initially, his knees were better and because I didn’t warn him sufficiently, he may have overdone it playing volleyball; nevertheless, they are still better than they were. I didn’t hear anything good about the shoulders but I did know the knees were still troublesome. Little did I know they completely recovered and no longer bother him at all.

As for my healing, I don't even THINK about my shoulders anymore ... it's like a non-issue. They work just fine 🙂
Vincent Spano
Actor, Producer

Regrowing a backbone

Another great example of a case that took a while to recover is Thalya who suffered a crushed verterbra June 2019 and was treated with lumbar epidural exosomes in November, 2019. The cruching persisted for months after the treatment but eventually, it subsided. When asked about the crunching in late August, 2020, she wrote:

The only crunching going on now is me eating tasty non-GMO potato chips, a household staple. Tomorrow I'll be swimming at Kaimana. My lower lumbar compression fracture from last year's (June '19) water skiing mishap seems healed now. It doesn't show any signs of injury in my daily functions. I haven't gone back to Zumba classes yet, but I may eventually take a chance on carefully trying those spinal twisting movements again. I'm able to do lots of hiking, swimming, and walking for exercise. I know the exosomes worked and I'm very grateful.

"The healing process is still unfolding"

Here is another patient, Mary Jo, age 66, who fell from a horse 24 years ago and had severe hip damage and nerve impingement since. She wrote one of the most eloquent descriptions of her recovery that reminded me of my blog on the “soft signs” of exosome healing. Perhaps, as she suggests, some cases are just a lot more complicated with layers of accumulated damage that need to be addressed:

Good to hear from you! I’m glad to be a part of this new age of medicine. I very much support the work you’re doing and appreciate all of your posts and blogs. Because I received exosomes IV, in both nostrils and in the lumbar spine my experience has been more global than local. I’ve experienced changes and or healing in areas of my body literally from head to toe. The only thing I can say I have observed overall is the intense sensations have moved from the extremities and other external areas of the body to more deep muscle areas in the core of the body. Right now for example, 12 weeks out from treatment, I’m experiencing the same intense feelings in my gluteus and hip flexors. Those areas of intensity last for at least 24-48 hours. That’s really the same thing I’ve experienced all over. The common thread is these are all areas of prior injury either directly or areas affected by the injury. One curious thing I notice is, if I remember six things that happened, it seems my body remembers more like sixty things, and we still have more to go. So with respect to these very intense sensations in different muscle groups, both in my extremities and in my deeper core, I find that this healing process is still unfolding. I have periods of a greater sense of well being and strength and some periods of difficulty when I still feel discomfort and can’t judge an outcome. Overall I would look forward to receiving additional exosome treatment in the future because it opens up a new pathway in the body for communication and ultimately for healing. It is a new way to build relationship with the body through an intervention to a biological field of information. A new way to bring about change through the regeneration, rejuvenation and reprogramming of cells through information and through expressed purpose. Who knows how many treatments or how much time may show greater improvement of a generative nature. I do know that with the reduction of inflammation in my body globally, as you described, I have experienced far less pain. Nothing in my outer world has fundamentally changed. I’ve not had any other treatments or even manual therapy in the last twelve weeks. Whatever changes I’ve experienced I would say are a result of exosomes.

If you are a patient and you have new improvements or even setbacks to report, please email me back so I can continue to learn. If you would like to refer someone or find out how I can help you, please reach out by email.

Feel free to bookmark the following link to have all my exosomes videos at your fingertips!

Archived exosome blogs….Please read them all at your convenience

I still have voluntary ASMR. Mom’s arthritis is greatly improved.

I explain why I believe exosomes aren’t inert. An amazing case of an overnight in heart rate variability is presented.

A case of whiplash and traumatic brain injury improved after exosome use.

After exosome injection, two runners were able to return to running after limitations from tendinosis that plagued them for months (in the case of the 60-yo man, and years (in the case of the 53-yo woman)

In this blog, I discussed how complicated clinical medicine can be. Different treatment protocols, ambiguous results ethical dilemmas and strange phenomena like acquired coffee aversion are part of what make treating with exosomes so challenging.

Using my left foot as an example, I attempt to explain that while some exosome effects are immediate, others take time. Remodeling of damaged tissues is a complicated process. My foot is still scarred and probably will be for life.

A patient after dental exosome injection becomes pain free after 4 years of suffering.

I explain why lab testing of freshly thawed exosomes is SUPPOSED to come back as normal saline.

A nine-part comprehensive explanation of exosomes.

I interviewed the principal scientists of Kimera Labs and other experienced clinicians using exosomes

66-yo Deb B went from not being able to do one squat to 100 per day after exosome injection.

80-yo Doug describes in his video how much his knees have improved since getting exosome injections. He is reaching new athletic peaks with no signs of stopping.

My 82-yo mom underwent microneedling with exosomes with fantastic results. Most impressive was the absence of “downtime” from redness or bruising.

54-yo weightlifter with chronic pain from a rotator cuff tear shows remarkable improvement in just four days! He re-injured it at the gym so had to undergo a repeat shoulder injection

48-yo woman with severe face blindness experiences some improvement after nasal injections of exosomes. Her ability to remember new faces has improved permanently

I delivered two lectures in Hawaii. The first was about exosomes generally and the second is a password-protected video about clinical applications.

Three cases of middle-aged women reporting enhanced enjoyment and renewed capacity to read after nasal exosome therapy

Two cases of improved dental health presented. We discuss the hazards of EMF and the promising future of dental regenerative therapy

We discuss the notion of energy centers known as chakras and the fact that we are electrical beings

A case of improvement in Seborrheoic Dermatitis after microneedling with MSC exosomes is presented.

I explain how poor we are at assessing change and how attribution and recall bias play important roles

In the past year, there has been a lot of shifting loyalties in the exosome space resulting in a lot of rumor, innuendo, and bad press. With various parties trying to get each other in trouble with federal regulators, it is a treacherous business to be in.

I describe a case of an 86-yo woman whose chronic leg rash disappeared after improvement in her leg circulation

I use a car wash analogy to answer the question “how long do exosomes last?” The answer is it depends on how dirty and damaged the car is, how well you clean it, and how dirty you get it after washing.

I describe four cases of improvement of osteoartritic knees from my trip to Hawaii.

I explain the three definitions of placebo and why I believe most of the effects of exosomes cannot be attributed to the so-called placebo effect.

Some remarkable “soft signs” of exosome effects include itching (new nerves), twitching (new muscles), and heaviness (a healing FORCE).

Three amigos came to see me and all enjoyed benefits. The best was the 48-yo gentleman who had a dramatic improvements to his irritable bowel syndrome, varicose veins, and appearance.

I address the common observation from patients that exosomes seem “smart” or that they know where to go. In fact, I doubt this is true and that they are no smarter than player piano scrolls are good musicians.

I gave a lecture at the University of Hawaii with about 80 attendees. Around 10 of them were actual patients. Hear in their own words how exosomes helped them.

I describe two cases of improved leg swelling and explain what causes this common condition and how exosomes may be improving it.

We present an amazing case of overnight nerve regeneration after ultrasound-targeted exosome injections.

A fascinating case of resumption of menstruation after taking IV exosomes

I speculate why a patient reported improvement in her double vision after exosome injection

My mom used to have cold hands and feet. Now she does not. I present a new technique for arterial and peri-arterial injection of exosomes

I review a case of tinnitus that improved after exosome use and explain the common condition

I reviewed 89 patients and 144 encounters in 256 sites. Overall, very good response rates and safety.

I present the case of a 69yo woman with a 12-yr history of Bell’s Palsy that improved overnight

1 thought on “Exosomes 39: The delayed reactions”

  1. I’m glad your move went well and you are now back to posting exosomes blogs! Thanks for the updates!

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